JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE) ›› 2021, Vol. 41 ›› Issue (8): 1089-1093.doi: 10.3969/j.issn.1674-8115.2021.08.015

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Research progress in the development of osteoarthritis mediated by pericellular matrix

Wen-cheng HU(), Hong-yi ZHU, Jun-qing LIN, Xian-you ZHENG()   

  1. Department of Orthopedic Surgery, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai 200233, China
  • Online:2021-08-28 Published:2021-07-28
  • Contact: Xian-you ZHENG;
  • Supported by:
    National Natural Science Foundation of China(81974331)


Osteoarthritis (OA) is one of the most common degenerative diseases in clinic. It causes joint pain and dyskinesia, and seriously affects the quality life of the patients′. However, the pathogenesis of OA has not been fully understood. Pericellular matrix (PCM) is a narrow matrix area around chondrocytes. Numerous evidences have revealed the promotion of PCM in the pathogenesis of osteoarthritis. The degradation of PCM components, the release of growth factor and the alteration of mechanical signal transduction accelerate the occurrence and development of OA. This paper summarizes the structure and functions of PCM, and reviews the latest progresses in the involvement of PCM in OA pathogenesis.

Key words: osteoarthritis (OA), pericellular matrix (PCM), chondron, mechanotransduction

CLC Number: