JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE) ›› 2021, Vol. 41 ›› Issue (11): 1514-1517.doi: 10.3969/j.issn.1674-8115.2021.11.017

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Research progress of the relationship between high-fat diet and colorectal cancer and its prevention and treatment countermeasures

Wen-hui XU(), Jing BIAN, Lei-zhen ZHENG()   

  1. Department of Oncology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
  • Online:2021-11-28 Published:2021-12-03
  • Contact: Lei-zhen ZHENG;
  • Supported by:
    National Natural Science Foundation of China(81974368)


Colorectal cancer (CRC) is one of the five malignant tumors in the world, with the second incidence rate and the third mortality of malignancy, which seriously threatens human life and health. Epidemiological studies show that the incidence rate of CRC in the economically developed countries is significantly higher than that in the underdeveloped countries, and that in city is higher than that in rural areas. The difference of CRC incidence populations in different geographical environments indicates that dietary factors can significantly affect incidence rate and prognosis of CRC. There is evidence that the western diet structure represented by high-fat diet is closely related to the occurrence and development of CRC, and exploring the related mechanism of high-fat diet in the process of CRC is very important to prevent the occurrence of CRC and improve the prognosis of the patients. This paper summarizes the relevant mechanism between high-fat diet and the occurrence and development of CRC at home and abroad in recent years, and puts forward the corresponding prevention strategies, so as to provide theoretical reference for the diet structure-related research and the prevention, diagnosis and treatment of CRC from the perspective of precision medicine.

Key words: dietary factor, colorectal cancer (CRC), high-fat diet, personalized nutrition

CLC Number: