Research progress in the association between maternal prenatal polyunsaturated fatty acids and maternal and infant health

doi:10.3969/j.issn.1674-8115.2021.12.020

Abstract

Abstract:

The nutritional status during pregnancy is closely related to the pregnancy outcome of the mother and the health of the offspring. Long chain polyunsaturated fatty acids (PUFAs) mainly include docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), arachidonic acid (AA), α-linolenic acid (ALA) and linoleic acid (LA). DHA, EPA and AA in human body are mainly from diet or synthesized from essential fatty acids ALA and LA. As the important components of cholesterol esters, phospholipids and fat in human body, PUFAs play complex biological functions through a variety of ways. For instance, PUFAs can participate in the composition of cell membrane, work as the second messenger precursors to transmit signals, and transform into hormones and PUFAs derivatives. Lack of PUFAs (EPA and DHA) during pregnancy may be related to the increased risk of preeclampsia, preterm delivery and postpartum depression, and affect the long-term cardiovascular health of children, but these correlations are still controversial. The increased intake of n-3 PUFAs (EPA and DHA) during pregnancy might be associated with the reduced risk of wheezing and asthma, while the increased intake of n-6 PUFAs (AA) might be associated with the increased risk of asthma and allergic rhinitis. For premature infants with insufficient DHA, timely supplementation of DHA could promote neurodevelopment. At present, there is a lack of normal reference range of PUFAs for pregnant women and newborns as the sensitive population. Thus, it is necessary to further study and establish the normal reference range of PUFAs in order to reasonably guide the nutrition of PUFAs during pregnancy.

Key words: polyunsaturated fatty acid (PUFA), maternal and infant health, docosahexaenoic acid (DHA)

CLC Number:

R151

Rui MA, Shu-jin CHEN, Feng-xiu OUYANG. Research progress in the association between maternal prenatal polyunsaturated fatty acids and maternal and infant health[J]. JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE), 2021, 41(12): 1684-1690.

Figures/Tables 3

TrendMD

References 87

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Author （Year）	Region	Sample size/n	Pregnancy	Sample	DHA/%	EPA/%	AA/%
Araujo （2020） ^［20］	Norway	247	17‒40 week	Erythrocyte	6.92 （mean）	0.79 （mean）	10.84 （mean）
Nita （2020） ^［21］	Japan	416	24‒30 week	Erythrocyte	7.44±1.12	0.74 （0.55‒1.04）	11.38±1.03
Hoge （2018） ^［18］	Belgium	122	1st trimester	Erythrocyte	5.27±1.42	0.51±0.25	14.30±1.26
Kitamura （2017） ^［22］	Japan	213	1st trimester	Erythrocyte	6.23±1.14	0.98±0.38	10.96±1.43
Barrera （2018） ^［23］	Chile	60	2nd trimester	Erythrocyte	4.16±0.60	0.98±0.10	12.90±1.20
Much （2013） ^［24］	Germany	102	2nd trimester	Erythrocyte	4.54±1.24	0.41±0.15	12.51±2.30
Steer （2012） ^［25］	England	4 346	≥20 weeks	Erythrocyte	2.01 （1.24‒3.05）	0.24 （0.16‒0.36）	6.09 （3.89‒8.36）
Kitamura （2017） ^［22］	Japan	213	3rd trimester	Erythrocyte	5.86±1.01	0.80±0.39	8.83±1.36
Gellert （2016） ^［26］	Germany	213	3rd trimester	Erythrocyte	6.10±1.29	0.52±0.19	13.88±1.68
Matsumoto （2020） ^［27］	Japan	204	24‒30 weeks	Plasma	5.66 （median）	0.85 （median）	8.28 （median）
Voortman （2018） ^［28］	Netherlands	6 999	2nd trimester	Plasma	4.67 （median）	0.44 （median）	9.72 （median）
Wolfe （2011） ^［29］	America	52	Delivery	Serum	2.07 （median）	0.27 （median）	4.94 （median）

Author （Year）	Region	Sample size/n	Pregnancy	Sample	DHA/%	EPA/%	AA/%
Araujo （2020） ^［20］	Norway	247	17‒40 week	Erythrocyte	6.92 （mean）	0.79 （mean）	10.84 （mean）
Nita （2020） ^［21］	Japan	416	24‒30 week	Erythrocyte	7.44±1.12	0.74 （0.55‒1.04）	11.38±1.03
Hoge （2018） ^［18］	Belgium	122	1st trimester	Erythrocyte	5.27±1.42	0.51±0.25	14.30±1.26
Kitamura （2017） ^［22］	Japan	213	1st trimester	Erythrocyte	6.23±1.14	0.98±0.38	10.96±1.43
Barrera （2018） ^［23］	Chile	60	2nd trimester	Erythrocyte	4.16±0.60	0.98±0.10	12.90±1.20
Much （2013） ^［24］	Germany	102	2nd trimester	Erythrocyte	4.54±1.24	0.41±0.15	12.51±2.30
Steer （2012） ^［25］	England	4 346	≥20 weeks	Erythrocyte	2.01 （1.24‒3.05）	0.24 （0.16‒0.36）	6.09 （3.89‒8.36）
Kitamura （2017） ^［22］	Japan	213	3rd trimester	Erythrocyte	5.86±1.01	0.80±0.39	8.83±1.36
Gellert （2016） ^［26］	Germany	213	3rd trimester	Erythrocyte	6.10±1.29	0.52±0.19	13.88±1.68
Matsumoto （2020） ^［27］	Japan	204	24‒30 weeks	Plasma	5.66 （median）	0.85 （median）	8.28 （median）
Voortman （2018） ^［28］	Netherlands	6 999	2nd trimester	Plasma	4.67 （median）	0.44 （median）	9.72 （median）
Wolfe （2011） ^［29］	America	52	Delivery	Serum	2.07 （median）	0.27 （median）	4.94 （median）

Author （Year）	Region	Sample size/n	Sample	DHA/%	EPA/%	AA/%
Nita （2020） ^［21］	Japan	383	Erythrocyte	6.79±0.93	0.28 （0.20‒0.39）	15.35±1.28
Kitamura （2018） ^［33］	Japan	114	Erythrocyte	7.54±0.08	0.43±0.02	16.03±0.11
Much （2013） ^［24］	Germany	65	Erythrocyte	2.54±2.19	0.08±0.06	7.62±4.85
Matsumoto （2020） ^［27］	Japan	203	Plasma	5.98 （median）	0.60 （median）	17.06 （median）
Montes （2013） ^［34］	Spain	170	Plasma	4.53±1.12	0.19±0.11	14.13±1.84
Steer （2012） ^［25］	England	3 394	Plasma	2.45 （1.85‒3.44）	0.19 （0.14‒0.25）	8.94 （7.16‒11.53）
Kohlboeck （2011） ^［35］	Germany	416	Serum	7.15±1.33	0.30±0.13	18.03±1.55
Wolfe （2011） ^［29］	America	52	Serum	3.24 （median）	1.06 （median）	9.64 （median）

Author （Year）	Region	Sample size/n	Sample	DHA/%	EPA/%	AA/%
Nita （2020） ^［21］	Japan	383	Erythrocyte	6.79±0.93	0.28 （0.20‒0.39）	15.35±1.28
Kitamura （2018） ^［33］	Japan	114	Erythrocyte	7.54±0.08	0.43±0.02	16.03±0.11
Much （2013） ^［24］	Germany	65	Erythrocyte	2.54±2.19	0.08±0.06	7.62±4.85
Matsumoto （2020） ^［27］	Japan	203	Plasma	5.98 （median）	0.60 （median）	17.06 （median）
Montes （2013） ^［34］	Spain	170	Plasma	4.53±1.12	0.19±0.11	14.13±1.84
Steer （2012） ^［25］	England	3 394	Plasma	2.45 （1.85‒3.44）	0.19 （0.14‒0.25）	8.94 （7.16‒11.53）
Kohlboeck （2011） ^［35］	Germany	416	Serum	7.15±1.33	0.30±0.13	18.03±1.55
Wolfe （2011） ^［29］	America	52	Serum	3.24 （median）	1.06 （median）	9.64 （median）

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