Journal of Shanghai Jiao Tong University (Medical Science) ›› 2023, Vol. 43 ›› Issue (8): 1049-1055.doi: 10.3969/j.issn.1674-8115.2023.08.014
• Review • Previous Articles
XUAN Zhenquan(), CHEN Xuanyi, YAO Zhirong()
Received:
2023-03-29
Accepted:
2023-06-29
Online:
2023-08-28
Published:
2023-08-28
Contact:
YAO Zhirong
E-mail:397703545@sjtu.edu.cn;yaozhirong@xinhuamed.com.cn
Supported by:
CLC Number:
XUAN Zhenquan, CHEN Xuanyi, YAO Zhirong. Research progress in neuroimmune disorders in atopic dermatitis[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2023, 43(8): 1049-1055.
Add to citation manager EndNote|Ris|BibTeX
URL: https://xuebao.shsmu.edu.cn/EN/10.3969/j.issn.1674-8115.2023.08.014
1 | GUO Y F, LI P, TANG J P, et al. Prevalence of atopic dermatitis in Chinese children aged 1-7 ys[J]. Sci Rep, 2016, 6: 29751. |
2 | LAUGHTER M R, MAYMONE M C, MASHAYEKHI S, et al. The global burden of atopic dermatitis: lessons from the Global Burden of Disease Study 1990‒2017[J]. Br J Dermatol, 2021, 184(2): 304-309. |
3 | FRAZIER W, BHARDWAJ N. Atopic dermatitis: diagnosis and treatment[J]. Am Fam Physician, 2020, 101(10): 590-598. |
4 | LANGAN S M, IRVINE A D, WEIDINGER S. Atopic dermatitis[J]. Lancet, 2020, 396(10247): 345-360. |
5 | TÜZÜN Y, ANTONOV M, DOLAR N, et al. Keratinocyte cytokine and chemokine receptors[J]. Dermatol Clin, 2007, 25(4): 467-476, vii. |
6 | KLEIN WOLTERINK R G J, WU G S, CHIU I M, et al. Neuroimmune interactions in peripheral organs[J]. Annu Rev Neurosci, 2022, 45: 339-360. |
7 | STEINHOFF M, AHMAD F, PANDEY A, et al. Neuroimmune communication regulating pruritus in atopic dermatitis[J]. J Allergy Clin Immunol, 2022, 149(6): 1875-1898. |
8 | CHURCH M K. Allergy, histamine and antihistamines[J]. Handb Exp Pharmacol, 2017, 241: 321-331. |
9 | BAUTISTA D M, WILSON S R, HOON M A. Why we scratch an itch: the molecules, cells and circuits of itch[J]. Nat Neurosci, 2014, 17(2): 175-182. |
10 | SCHAPER-GERHARDT K, ROSSBACH K, NIKOLOULI E, et al. The role of the histamine H4 receptor in atopic dermatitis and psoriasis[J]. Br J Pharmacol, 2020, 177(3): 490-502. |
11 | MURATA Y, SONG M, KIKUCHI H, et al. Phase 2a, randomized, double-blind, placebo-controlled, multicenter, parallel-group study of a H4 R-antagonist (JNJ-39758979) in Japanese adults with moderate atopic dermatitis[J]. J Dermatol, 2015, 42(2): 129-139. |
12 | YOSIPOVITCH G, ROSEN J D, HASHIMOTO T. Itch: from mechanism to (novel) therapeutic approaches[J]. J Allergy Clin Immunol, 2018, 142(5): 1375-1390. |
13 | CHAN L S, ROBINSON N, XU L. Expression of interleukin-4 in the epidermis of transgenic mice results in a pruritic inflammatory skin disease: an experimental animal model to study atopic dermatitis[J]. J Invest Dermatol, 2001, 117(4): 977-983. |
14 | ZHENG T, OH M H, OH S Y, et al. Transgenic expression of interleukin-13 in the skin induces a pruritic dermatitis and skin remodeling[J]. J Invest Dermatol, 2009, 129(3): 742-751. |
15 | OETJEN L K, MACK M R, FENG J, et al. Sensory neurons co-opt classical immune signaling pathways to mediate chronic itch[J]. Cell, 2017, 171(1): 217-228. e13. |
16 | SINGER E M, SHIN D B, NATTKEMPER L A, et al. IL-31 is produced by the malignant T-cell population in cutaneous T-Cell lymphoma and correlates with CTCL pruritus[J]. J Invest Dermatol, 2013, 133(12): 2783-2785. |
17 | SONKOLY E, MULLER A, LAUERMA A I, et al. IL-31: a new link between T cells and pruritus in atopic skin inflammation[J]. J Allergy Clin Immunol, 2006, 117(2): 411-417. |
18 | TEY H L, CAO T, NATTKEMPER L A, et al. Pathophysiology of pruritus in primary localized cutaneous amyloidosis[J]. Br J Dermatol, 2016, 174(6): 1345-1350. |
19 | CEVIKBAS F, WANG X, AKIYAMA T, et al. A sensory neuron-expressed IL-31 receptor mediates T helper cell-dependent itch: involvement of TRPV1 and TRPA1[J]. J Allergy Clin Immunol, 2014, 133(2): 448-460. |
20 | BECK L A, CORK M J, AMAGAI M, et al. Type 2 inflammation contributes to skin barrier dysfunction in atopic dermatitis[J]. JID Innov, 2022, 2(5): 100131. |
21 | SOUMELIS V, RECHE P A, KANZLER H, et al. Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP[J]. Nat Immunol, 2002, 3(7): 673-680. |
22 | WILSON S R, THÉ L, BATIA L M, et al. The epithelial cell-derived atopic dermatitis cytokine TSLP activates neurons to induce itch[J]. Cell, 2013, 155(2): 285-295. |
23 | LEE W J, SHIM W S. Cutaneous neuroimmune interactions of TSLP and TRPV4 play pivotal roles in dry skin-induced pruritus[J]. Front Immunol, 2021, 12: 772941. |
24 | OYOSHI M K, LARSON R P, ZIEGLER S F, et al. Mechanical injury polarizes skin dendritic cells to elicit a TH2 response by inducing cutaneous thymic stromal lymphopoietin expression[J]. J Allergy Clin Immunol, 2010, 126(5): 976-984, 984. e1-5. |
25 | CHAN B C L, LAM C W K, TAM L S, et al. IL33: roles in allergic inflammation and therapeutic perspectives[J]. Front Immunol, 2019, 10: 364. |
26 | HUANG J T, GANDINI M A, CHEN L N, et al. Hyperactivity of innate immunity triggers pain via TLR2-IL-33-mediated neuroimmune crosstalk[J]. Cell Rep, 2020, 33(1): 108233. |
27 | LIU B Y, TAI Y, ACHANTA S, et al. IL-33/ST2 signaling excites sensory neurons and mediates itch response in a mouse model of poison ivy contact allergy[J]. Proc Natl Acad Sci USA, 2016, 113(47): E7572-E7579. |
28 | TRIER A M, MACK M R, FREDMAN A, et al. IL-33 signaling in sensory neurons promotes dry skin itch[J]. J Allergy Clin Immunol, 2022, 149(4): 1473-1480. e6. |
29 | NAKAMURA N, TAMAGAWA-MINEOKA R, YASUIKE R, et al. Stratum corneum interleukin-33 expressions correlate with the degree of lichenification and pruritus in atopic dermatitis lesions[J]. Clin Immunol, 2019, 201: 1-3. |
30 | ROGGENKAMP D, FALKNER S, STÄB F, et al. Atopic keratinocytes induce increased neurite outgrowth in a coculture model of porcine dorsal root ganglia neurons and human skin cells[J]. J Invest Dermatol, 2012, 132(7): 1892-1900. |
31 | SOLINSKI H J, RUKWIED R, SCHMELZ M. Microinjection of pruritogens in NGF-sensitized human skin[J]. Sci Rep, 2021, 11(1): 21490. |
32 | TAKANO N, SAKURAI T, OHASHI Y, et al. Effects of high-affinity nerve growth factor receptor inhibitors on symptoms in the NC/Nga mouse atopic dermatitis model[J]. Br J Dermatol, 2007, 156(2): 241-246. |
33 | KOWIAŃSKI P, LIETZAU G, CZUBA E, et al. BDNF: a key factor with multipotent impact on brain signaling and synaptic plasticity[J]. Cell Mol Neurobiol, 2018, 38(3): 579-593. |
34 | FÖLSTER-HOLST R, PAPAKONSTANTINOU E, RÜDRICH U, et al. Childhood atopic dermatitis-brain-derived neurotrophic factor correlates with serum eosinophil cationic protein and disease severity[J]. Allergy, 2016, 71(7): 1062-1065. |
35 | GUSEVA D, RÜDRICH U, KOTNIK N, et al. Neuronal branching of sensory neurons is associated with BDNF-positive eosinophils in atopic dermatitis[J]. Clin Exp Allergy, 2020, 50(5): 577-584. |
36 | MUROTA H, IZUMI M, ABD EL-LATIF M I, et al. Artemin causes hypersensitivity to warm sensation, mimicking warmth-provoked pruritus in atopic dermatitis[J]. J Allergy Clin Immunol, 2012, 130(3): 671-682. e4. |
37 | HIDAKA T, OGAWA E, KOBAYASHI E H, et al. The aryl hydrocarbon receptor AhR links atopic dermatitis and air pollution via induction of the neurotrophic factor artemin[J]. Nat Immunol, 2017, 18(1): 64-73. |
38 | JÄRVIKALLIO A, HARVIMA I T, NAUKKARINEN A. Mast cells, nerves and neuropeptides in atopic dermatitis and nummular eczema[J]. Arch Dermatol Res, 2003, 295(1): 2-7. |
39 | SALOMON J, BARAN E. The role of selected neuropeptides in pathogenesis of atopic dermatitis[J]. J Eur Acad Dermatol Venereol, 2008, 22(2): 223-228. |
40 | KUBANOV A A, KATUNINA O R, CHIKIN V V. Expression of neuropeptides, neurotrophins, and neurotransmitters in the skin of patients with atopic dermatitis and psoriasis[J]. Bull Exp Biol Med, 2015, 159(3): 318-322. |
41 | HAN S B, KIM H, CHO S H, et al. Protective effect of botulinum toxin type A against atopic dermatitis-like skin lesions in NC/Nga mice[J]. Dermatol Surg, 2017, 43(Suppl 3): S312-S321. |
42 | YIN Q Q, SUN L B, CAI X J, et al. Lidocaine ameliorates psoriasis by obstructing pathogenic CGRP signaling-mediated sensory neuron-dendritic cell communication[J]. J Invest Dermatol, 2022, 142(8): 2173-2183. e6. |
43 | ROGGENKAMP D, KÖPNICK S, STÄB F, et al. Epidermal nerve fibers modulate keratinocyte growth via neuropeptide signaling in an innervated skin model[J]. J Invest Dermatol, 2013, 133(6): 1620-1628. |
44 | SHI X, WANG L, CLARK J D, et al. Keratinocytes express cytokines and nerve growth factor in response to neuropeptide activation of the ERK1/2 and JNK MAPK transcription pathways[J]. Regul Pept, 2013, 186: 92-103. |
45 | ANTÚNEZ C, TORRES M J, LÓPEZ S, et al. Calcitonin gene-related peptide modulates interleukin-13 in circulating cutaneous lymphocyte-associated antigen-positive T cells in patients with atopic dermatitis[J]. Br J Dermatol, 2009, 161(3): 547-553. |
46 | SUN P Y, LI H G, XU Q Y, et al. Lidocaine alleviates inflammation and pruritus in atopic dermatitis by blocking different population of sensory neurons[J]. Br J Pharmacol, 2023, 180(10): 1339-1361. |
47 | LIU J Y, HU J H, ZHU Q G, et al. Effect of matrine on the expression of substance P receptor and inflammatory cytokines production in human skin keratinocytes and fibroblasts[J]. Int Immunopharmacol, 2007, 7(6): 816-823. |
48 | RAAP M, RÜDRICH U, STÄNDER S, et al. Substance P activates human eosinophils[J]. Exp Dermatol, 2015, 24(7): 557-559. |
49 | FRIEDMAN S, LEVI-SCHAFFER F. Substance P and eosinophils: an itchy connection[J]. Exp Dermatol, 2015, 24(12): 918-919. |
50 | PAVLOVIC S, DANILTCHENKO M, TOBIN D J, et al. Further exploring the brain-skin connection: stress worsens dermatitis via substance P-dependent neurogenic inflammation in mice[J]. J Invest Dermatol, 2008, 128(2): 434-446. |
51 | SERHAN N, BASSO L, SIBILANO R, et al. House dust mites activate nociceptor-mast cell clusters to drive type 2 skin inflammation[J]. Nat Immunol, 2019, 20(11): 1435-1443. |
52 | WHEELER J J, LASCELLES B D, OLIVRY T, et al. Itch-associated neuropeptides and their receptor expression in dog dorsal root ganglia and spinal cord[J]. Acta Derm Venereol, 2019, 99(12): 1131-1135. |
53 | MENG J, MORIYAMA M, FELD M, et al. New mechanism underlying IL-31-induced atopic dermatitis[J]. J Allergy Clin Immunol, 2018, 141(5): 1677-1689. e8. |
54 | GOODERHAM M J, HONG H C, ESHTIAGHI P, et al. Dupilumab: a review of its use in the treatment of atopic dermatitis[J]. J Am Acad Dermatol, 2018, 78(3 Suppl 1): S28-S36. |
55 | NEZAMOLOLAMA N, FIELDHOUSE K, METZGER K, et al. Emerging systemic JAK inhibitors in the treatment of atopic dermatitis: a review of abrocitinib, baricitinib, and upadacitinib[J]. Drugs Context, 2020, 9: 2020-8-5. |
56 | WOLLENBERG A, WEIDINGER S, WORM M, et al. Tralokinumab in atopic dermatitis[J]. J Dtsch Dermatol Ges, 2021, 19(10): 1435-1442. |
57 | RUZICKA T, HANIFIN J M, FURUE M, et al. Anti-interleukin-31 receptor A antibody for atopic dermatitis[J]. N Engl J Med, 2017, 376(9): 826-835. |
58 | KABASHIMA K, MATSUMURA T, KOMAZAKI H, et al. Nemolizumab plus topical agents in patients with atopic dermatitis (AD) and moderate-to-severe pruritus provide improvement in pruritus and signs of AD for up to 68 weeks: results from two phase Ⅲ, long-term studies[J]. Br J Dermatol, 2022, 186(4): 642-651. |
59 | SILVERBERG J I, PINTER A, PULKA G, et al. Phase 2B randomized study of nemolizumab in adults with moderate-to-severe atopic dermatitis and severe pruritus[J]. J Allergy Clin Immunol, 2020, 145(1): 173-182. |
60 | WELSH S E, XIAO C, KADEN A R, et al. Neurokinin-1 receptor antagonist tradipitant has mixed effects on itch in atopic dermatitis: results from EPIONE, a randomized clinical trial[J]. J Eur Acad Dermatol Venereol, 2021, 35(5): e338-e340. |
61 | LEE Y W, WON C H, JUNG K, et al. Efficacy and safety of PAC-14028 cream - a novel, topical, nonsteroidal, selective TRPV1 antagonist in patients with mild-to-moderate atopic dermatitis: a phase Ⅱb randomized trial[J]. Br J Dermatol, 2019, 180(5): 1030-1038. |
62 | RATCHATASWAN T, BANZON T M, THYSSEN J P, et al. Biologics for treatment of atopic dermatitis: current status and future prospect[J]. J Allergy Clin Immunol Pract, 2021, 9(3): 1053-1065. |
63 | PENG G, MU Z Z, CUI L X, et al. Anti-IL-33 antibody has a therapeutic effect in an atopic dermatitis murine model induced by 2, 4-dinitrochlorobenzene[J]. Inflammation, 2018, 41(1): 154-163. |
64 | ZENG D, CHEN C, ZHOU W, et al. TRPA1 deficiency alleviates inflammation of atopic dermatitis by reducing macrophage infiltration[J]. Life Sci, 2021, 266: 118906. |
65 | LI H, LI C, ZHANG H, et al. Effects of lidocaine on regulatory T cells in atopic dermatitis[J]. J Allergy Clin Immunol, 2016, 137(2): 613-617. e5. |
66 | JIAO Q Q, WANG H L, HU Z L, et al. Lidocaine inhibits staphylococcal enterotoxin-stimulated activation of peripheral blood mononuclear cells from patients with atopic dermatitis[J]. Arch Dermatol Res, 2013, 305(7): 629-636. |
67 | DRUCKER A M, WANG A R, LI W Q, et al. The burden of atopic dermatitis: summary of a report for the National Eczema Association[J]. J Invest Dermatol, 2017, 137(1): 26-30. |
[1] | WANG Qing, HAN Xiao, ZHANG Xiaobo. Research progress of immune response regulated by epigenetic modification in pneumonia [J]. Journal of Shanghai Jiao Tong University (Medical Science), 2023, 43(7): 931-938. |
[2] | LIN Jiayu, QIN Jiejie, JIANG Lingxi. Progress in metabolism of the immune cells in tumor microenvironment [J]. Journal of Shanghai Jiao Tong University (Medical Science), 2022, 42(8): 1122-1130. |
[3] | ZHOU Han, YANG Xiao-sheng, LIAO Chen-long, ZHANG Wen-chuan. Analysis on characteristics of diabetic foot ulceration-related genes and immune cells [J]. JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE), 2020, 40(10): 1354-1359. |
[4] | WANG Dan-dan, ZHANG Chen. Research progress of neuroimmune mechanisms of cognitive function in schizophrenia and effect of atypical antipsychotic drugs on it [J]. , 2019, 39(7): 795-. |
Viewed | ||||||
Full text |
|
|||||
Abstract |
|
|||||