Abstract:

Objective To analyze the correlation between clinicopathologic factors and prognosis of primary gastrointestinal stromal tumors (GISTs). Methods The clinicopathologic data of 166 patients with primary GISTs were analyzed. The progression-free survival (PFS) of patients was compared using KaplanMeier method. The clinicopathologic factors affecting the prognosis of patients were investigated by univariate and multivariate analysis. Results Univariate analysis revealed that the prognosis of patients was associated with primary location, tumor size, mitotic index, invasion of surrounding tissues, necrosis, NIH risk and Ki-67 index. Multivariate analysis indicated that tumor size, invasion of surrounding tissues, necrosis, NIH risk and Ki-67 index were independent factors affecting the prognosis of patients. Conclusion The prognosis of primary GISTs can be assessed by combining the classical NIH risk classification, Ki-67 index and invasion of surrounding tissues.

Key words: primary gastrointestinal stromal tumors;progressfree survival, prognosis