Abstract:

Objective To explore the relationship between predictable ocular motor control and cognitive function in Parkinson's disease （PD）. Methods Videonystagmography was used to examine 24 patients with idiopathic PD (PD group) and 24 healthy controls (control group) on predictable ocular motor control. The accuracies of saccade were compared between two groups. The correlation among accuracy for predictive saccade （latency<80 ms）and MoCA score, score in motor portion of UPDRS and Hoehn-Yahr stage was analyzed. Results The accuracy of predictive saccade decreased significantly compared with unpredictive saccade in two groups (P<0.01). The total accuracy of saccade in PD group decreased significantly compared with that in control group (P=0.018). The decrease amplitude of predictive saccade in PD group was higher than that in control group (P=0.000). The accuracy of predictive saccade had correlation with MoCA score (correlation coefficient was 0.485, P=0.016), while had no correlation with scores in motor portion of UPDRS and Hoehn-Yahr stage (correlation coefficients were 0.087 and 0.007, P=0.686 and P=0.974, respectively). Conclusion Patients with PD have difficulties in predictive ocular motor control. The accuracy of predictive saccade is an objective parameter reflecting cognitive function in PD.

Key words: Parkinson´s disease, saccade, videonystagmography, cognitive function