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Study on the effects of ANK3 gene on the development of cognitive impairment in patients with schizophrenia

LÜ  Wang-qiang1, TANG Wei2, CAI Jun3, LU Wei-hong3, YU Yue-guo1, FAN Wei-xing1, ZHANG Chen1,3   

  1. 1.Jinhua Second Hospital, Jinhua 321016, China; 2.Wenzhou Kangning Hospital, Wenzhou 325000, China; 3.Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
  • Online:2016-09-28 Published:2016-10-31
  • Supported by:

    National Natural Science Foundation of China, 81471358; Jinhua Science and Technology Bureau Foundation, 2015-3-063; Shanghai Municipal Science and Technology Commission Foundation, 14411969000; Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support, 20152530; Shanghai Municipal Commission of Health and Family Planning Foundation, 201540029


Objective·To investigate the effects of ANK3 gene on the cognitive function in patients with schizophrenia. Methods·A total of 254 schizophrenia patients with stable condition and 72 healthy controls were recruited. Cognitive function was tested using RBANS and SNP rs10994336 was genotyped using TaqMan SNP genotyping assay. Results·The difference in sex between case group and control group was not statistically significant (P=0.18), while the differences in age and education were statistically significant (P<0.01). In the RBANS evaluation, patients in case group had much higher total scores and scores in immediate memory, visual span, language ability, attention, and delayed memory compared with the control group (P<0.01). The differences in the total score and scores of immediate memory, attention, and delayed memory between patients carrying three different genotypes of rs10994336 were statistically significant (P<0.01). Patients carrying T/T genotype had significantly lower RBANS scores than those carrying C/C genotype. Conclusion·ANK3 gene is significantly associated with cognitive impairment in patients with schizophrenia, especially in terms of immediate memory, attention, and delayed memory, suggesting ANK3 gene may participate in the development of cognitive impairment in patients with schizophrenia.

Key words: ANK3 gene, cognitive function, schizophrenia, genetic polymorphism, correlation analysis