›› 2012, Vol. 32 ›› Issue (3): 336-.doi: 10.3969/j.issn.1674-8115.2012.03.021

• Original article (Clinical research) • Previous Articles     Next Articles

Expression of sodium iodine symporter mRNA in benign or malignant thyroid diseases

HE Rui-ping1, WU Yi-jie2   

  1. 1.Department of Endocrinology, the Seventh People's Hospital, Shanghai 200137, China；2.Department of Endocrinology, the First People's Hospital, Shanghai Jiaotong University, Shanghai 200080, China
  • Online:2012-03-28 Published:2012-03-28

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Abstract:

Objective To investigate the expression of sodium iodine symporter (NIS) in thyroid tissues in benign or malignant thyroid diseases. Methods Fresh thyroid specimens were obtained from thyroid ablation operation, and were divided into nodular goiter group, thyroid adenoma group, thyroid carcinoma group and control group according to pathological findings. The expression of NIS mRNA in thyroid tissues of each group was detected by Real-Time PCR. Results The relative expression of NIS mRNA in nodular goiter group, thyroid adenoma group and thyroid carcinoma group was significantly lower than that in control group (P<0.01). The relative expression of NIS mRNA in thyroid carcinoma group was significantly lower than that in nodular goiter group and thyroid adenoma group (P<0.01). There was no significant difference in the relative expression of NIS mRNA between nodular goiter group and thyroid adenoma group (P>0.05). Conclusion The expression of NIS mRNA decreases both in benign thyroid diseases and in malignant diseases, especially for the latter, which indicates that “iodine pump” defects exist in different thyroid diseases.

Key words: sodium iodine symporter, thyroid disease, Real-Time PCR