Abstract:

Objective To investigate the effects of administration of parecoxib sodium at different time points on analgesia after modified radical mastectomy for breast cancer. Methods Sixty patients undergoing modified radical mastectomy for breast cancer under general anesthesia were selected and divided into four groups, with 15 patients in each group. Group A received 2 mL normal saline during anesthesia induction, group B 40 mg parecoxib sodium during anesthesia induction, group C 40 mg parecoxib sodium at the end of surgery, and group D 40 mg parecoxib sodium both during anesthesia induction and at the end of surgery. Parecoxib sodium was intravenously administered after dilution into 2 mL normal saline in group B, group C and group D. Fentanyl was supplemented to the requirement of patients during analepsia. Visual analogue scale (VAS) scores were recorded 2, 12 and 24 h after surgery, VAS motion scores and analgesic satisfaction rates were obtained 24 h after surgery, and the occurrence of nausea and vomiting were observed after surgery. Results The VAS scores 2, 12 and 24 h after surgery in group B, group C and group D were significantly lower than those in group A (P<0.01), and the VAS scores 12 h after surgery in group B and group D were significantly lower than those in group C (P<0.05). The VAS motion scores 24 h after surgery in group B, group C and group D were significantly lower than that in group A (P<0.01), and the VAS motion score 24 h after surgery in group B was significantly higher than that in group D (P<0.05). The analgesic satisfaction rates 24 h after surgery in group B, group C and group D were higher than that in group A. The prevalences of nausea and vomiting 12 and 24 h after surgery in group B, group C and group D were lower than those in group A. Conclusion Parecoxib sodium plays a role in preemptive analgesia for patients undergoing modified radical mastectomy for breast cancer, which may improve postoperative pain control and analgesic satisfaction rate and reduce the incidence of nausea and vomiting. Administration of parecoxib sodium both during anesthesia induction and at the end of the surgery may yield better results.

Key words: parecoxib sodium, postoperative analgesia, nausea and vomiting