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Clinical and pathological study of uterine serous carcinoma and its precancerous lesions in postmenopausal women

ZHOU Xiao-fei1,2, ZHONG Yi-cun1   

  1. 1.Department of Obstetrics and Gynecology, Shanghai Key Laboratory of Gynecologic Oncology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China; 2.Department of Obstetrics and Gynecology, People′s Hospital of Jilin Province, Changchun 130021, China
  • Online:2014-01-28 Published:2014-01-29

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Abstract:

Objective To study the correlationship of morphology and immunohistochemistry of uterine serous carcinoma (USC) and its precancerous lesion of endometrial glandular dysplasia (EmGD) in the postmenopausal women. Methods The clinical and pathological manifestations of 14 cases of USC and EmGD were analyzed retrospectively. Immunohistochemical SP method was used to detect the expression of P53 protein, Ki-67 index, estrogen receptor (ER), and progestrone receptor (PR) in the tissues. And 10 cases of normal postmenopausal endometrium were enrolled as control group. Results The clinical and pathological features of USC and EmGD were distinctive. Compared to normal endometrium tissues, the local expression of P53 protein and the Ki-67 index in USC were the highest, meanwhile the local expression of P53 and Ki-67 index in EmGD were between those in USC and in normal endometrium. Conclusion There is significant correlation between EmGD and USC, the former can be regarded as precancerous lesion of USC. In addition to treat the patients with USC comprehensively, we also should take active and effective measures to deal with patients with EmGD to block the occurrence of USC.

Key words: uterine serous carcinoma, endometrial glandular dysplasia, precancerous lesions, P53 protein, Ki-67 index