Abstract:

Objective To analyze the clinicopathologic features of cervical mucinous adenocarcinoma in order to provide reference for its diagnosis, treatment, and prognosis. Methods The clinical and pathological manifestations of 35 patients with cervical mucinous adenocarcinoma were retrospectively analyzed. The expressions of human papilloma virus and carcino-embryonic antigen were detected by using SP immunohistochemical method. Results Among 35 cases, 32 were endocervical type, 2, minimal deviation; and 2, villoglandular. The positive rate of cervical cytology was 42.9% (15/35). Missed diagnosis was found in 4 cases. One case was missed in cervical smears; 1, cervical biopsy diagnosis; and 2, abnormal gland cells in cervical biopsy. The 2 with abnormal gland cells were diagnosed as cervical invasive adenocarcinoma by loopelectrosurgical excision procedure. Immunohistochemical staining results showed that 26 had positive expressions of carcinoembryonic antigen （26/35, 74.3%）, and 14 had positive expressions of human papilloma virus (14/35, 40.0%). Among the 14 patients, 8 had squamous intraepithelial lesions. Conclusion Cervical cytological test is effective in the diagnosis of cervical mucinous adenocarcinoma. Early stage cervical mucinous adenocarcinoma is difficult to be detected. Cervical excisional biopsy and endocervical curettage are beneficial to its diagnosis.

Key words: cervical mucinous adenocarcinoma, pathological diagnosis, clinical characteristics, missed diagnosis