Objective To investigate the effects of different mediums (air, water, and glaze liquid) and different abutment colors on the final color of all-ceramic veneer. Methods Specimens of different abutment colors (ND1-ND7) and IPS e.max CAD LTA1 0.7 mm ceramics slices were superposed and the final color of veneers of restorations was measured by the color spectrometer. The color difference (ΔE) was calculated according to reference colors of 2 mm LTA1 and LTA2 ceramic blocks. Two-way ANOVA analysis was carried out based on ΔE values of ND1-ND6 and Tamhane T2 test was performed for multiple comparisons. Results Both mediums and abutment colors affected ΔE values and the interactive effect existed between two factors (P<0.05). The differences of ΔE values of air and water, and air and glaze liquid were statistically significant (P<0.05), while the differences of ΔE values of water and glaze liquid were not statistically significant (P>0.05). The effect of different mediums on the lightness of restorations was the most significant. Conclusion All of mediums air, water, and glaze liquid affect the color of allceramic veneer. The effect of mediums on the lightness is the most significant. The interactive effect exists between mediums and abutment colors. Water and glaze liquid can make the color of all-ceramic veneer closer to the target color. Maintenance of a certain degree of moisture benefits the color matching.