Abstract:

Objective To investigate the effects of P2Y12 receptor antagonist on the growth of tumor. Methods Two kinds of nude mice transplanted tumor models HT29 and MDA231 were established. Mice were randomly divided into the control group, clopidogrel group, and ticagrelor group. For HT29 transplanted tumor model, the numbers of nude mice of control group, clopidogrel group, and ticagrelor group were 20, 20, and 19, respectively. For MDA231 transplanted tumor model, the numbers of nude mice of control group, clopidogrel group, and ticagrelor group were all 4. Mice of three groups were intragastric administration with phosphate buffer solution, clopidogrel suspension, and ticagrelor suspension, respectively and sacrificed after 10 d. The weight and body surface area of tumors were measured and the effects of P2Y12 receptor antagonist on the growth of tumor were observed. Results For HT29 transplanted tumor model, the weight and body surface area of tumors of the control group, clopidogrel group, and ticagrelor group were (1.20±0.12) g and (233.60±20.77)mm², (0.99±0.08) g and (192.30±13.28)mm², and (1.04±0.11) g and (211.10±19.21) mm², respectively. The differences of the weight and body surface area of tumors of three groups were not statistically significant (P>0.05). For MDA231 transplanted tumor model, the weight and body surface area of tumors of the control group, clopidogrel group, and ticagrelor group were (0.65±0.17) g and (149.80±27.08) mm², (1.04±0.24) g and (183.80±30.18) mm², and (1.08±0.35) g and (201.30±45.62) mm², respectively. The differences of the weight and body surface area of tumors of three groups were not statistically significant (P>0.05). Conclusion P2Y12 receptor antagonist has no remarkable effect on the growth of transplanted tumor of nude mice.

Key words: P2Y12 receptor antagonist, platelet, transplanted tumor model