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Correlation between γ-glutamyltransferase and hyperuricemia of male populations with metabolic syndrome

GU Jing-li, CAO Qin, HUANG Rong, GU Wei-wei, MA Jia-hua, FAN Zhu-ping   

  1. Department of Health Care Center, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
  • Online:2015-08-28 Published:2015-09-30

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Abstract:

Objective  To investigate the effects of different levels of serum γ-glutamyltransferase (GGT) of male patients with metabolic syndrome (MS) on hyperuricemia (HUA). Methods  A total of 11 427 male adults who underwent the physical examination from January to December, 2012 at the physical examination center of a third level grade A hospital were selected as subjects and divided into the MS group (n=2 908) and normal control group (n=8 519). Their BMI, SBP, DBP, SUA, ALT, GGT, FPG, T-Ch, TAG, HDL-Ch, and LDL-Ch were measured. According to the GGT level, subjects were divided into 4 groups based on the quartile method. The effects of high quartile groups and low quartile groups on HUA were compared and multivariate non conditional Logistic regression analysis was adopted. Results  Compared with the normal control group, mean levels of BMI, SBP, DBP, SUA, ALT, GGT, FPG, TAG, T-Ch, and LDL-Ch of the MS group were significantly higher (P<0.001), HDL-Ch was significantly lower (P<0.001), and the incidence of fatty liver was significantly higher (P<0.001). The differences of above indexes of high quartile groups and low quartile groups were statistically significant (P<0.05). For the MS group, compared with low quartile groups, the OR value of the risk of HUA of high quartile groups was 3.09 after the indexes were corrected (P<0.01). For the normal control group, compared with low quartile groups, the OR value of the risk of HUA of high quartile groups was 2.17 (P<0.01). Conclusion  For male population with MS, the increase of GGT level indicates significant increase of the risk of HUA. Even for male population with normal components of MS, the risk of HUA also increases with the GGT level. So for clinical treatment and protection, more attention should be paid to the health management of GGT, including its level and dynamic change. Timely intervention should be performed and the incidence and development of relevant diseases should be concerned.

Key words: &gamma, -glutamyltransferase； hyperuricemia； metabolic syndrome； risk factor