›› 2018, Vol. 38 ›› Issue (3): 328-.doi: 10.3969/j.issn.1674-8115.2018.03.016

• Review • Previous Articles     Next Articles

Research advances in the role of inflammatory factors in polycystic ovary syndrome

LIU Lan-xin1 , ZHOU Cheng-liang2 , YANG Qian1 , HUANG He-feng1, 2   

  1. 1. Institute of Embryonic Source Diseases, International Peace Maternity & Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China; 2. Key Laboratory of Reproductive Genetics (Ministry of Education), Women's Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China
  • Online:2018-03-28 Published:2018-05-03
  • Supported by:
    National Key Technology Support Program, 2012BAI32B00; National Natural Science Foundation of China, 81450038

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Abstract: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder affecting women of childbearing age, which features oligo- or
anovulation, polycystic ovaries, hyperandrogenism and the related clinical signs, such as acne and hirsutism. At present, PCOS patients are considered
to be in a long-time condition of chronic inflammation. It is reported that increased expression of inflammatory factors and/or increased levels of
inflammation exist in peripheral blood, granulosa cells, follicular fluid, ovarian stroma, adipocytes and endometrial cells in patients with PCOS. Studies
on the role of inflammatory factors in the pathogenesis of PCOS suggest that inflammatory factors may have an influence on the clinical outcome through
affecting follicular development, androgen levels and so on.