Abstract: Objective · To explore the application and clinical significance of mixed reality technology in percutaneous vertebroplasty of spine. Methods · A 79-year-old female patient with multiple osteoporotic compression fractures was selected in Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine. Lumbar 64-row CT scan was performed to obtain digital imaging and communications in medicine (DICOM) data. Three-dimensional reconstruction software was imported to construct the model of spinal compression fracture. Visual edge detection, segmentation, extraction and calculation of spinal skeleton were performed to generate a three-dimensional network. Collateral model,mixed reality smartglasses，three-dimensional image of the compression spine image was compared to the real world. Mixed reality technology could assist the surgeon to complete the preoperative simulation, communicate effectively with the patient, and guide percutaneous vertebroplasty of lumber. Results · With mixed reality, the puncture was accurate. The distribution of bone cement was good. The pain of patients was relieved obviously after operation.mixed reality, the operation time was shortened and the side-effects were reduced. Based on reconstruction of mixed reality technology original CT imaging data, the compression fracture and anatomical structure were visualized clearly during operation. The operation path was clear and the compression fracture forming site was accurately located. Conclusion ·Mixed reality technology is helpful for accurate puncture in percutaneous vertebroplasty of spine, and has potential for development in minimally invasive treatment of spine.

Key words: mixed reality (MR), percutaneous vertebroplasty of spine, precision medicine, virtual reality