›› 2020, Vol. 40 ›› Issue (4): 514-.doi: 10.3969/j.issn.1674-8115.2020.04.016

• Original article (Clinical research) • Previous Articles     Next Articles

Value of contrast-enhanced ultrasound quantitative analysis in differential diagnosis of benign and malignant breast intraductal lesions

WANG Mei-yu, ZHANG Yi-feng, CHEN Jie, ZHENG Li   

  1. 1. Department of Ultrasound, Baoshan Integrated Traditional Chinese and Western Medicine Hospital, Shanghai 201999, China; 2. Department of Medical Ultrasound, Shanghai Tenth Peoples Hospital, Tongji University School of Medicine, Shanghai 200072, China; 3. Ultrasound Research and Education Institute, Tongji University Cancer Center, Shanghai Engineering Research Center of Ultrasound Diagnosis and Treatment, Tongji University School of Medicine, Shanghai 200072, China
  • Online:2020-04-28 Published:2020-05-22

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Abstract: Objective · To evaluate the value of contrast-enhanced ultrasound quantitative analysis in the differential diagnosis of benign and malignant breast intraductal lesions. Methods · A retrospective analysis was made on the characteristics of conventional ultrasound and the time-intensity curve (TIC) of contrast-enhanced ultrasound (CEUS) of 71 breast intraductal lesions in 63 patients, which were surgically resected and pathologically confirmed in Shanghai Tenth People′s Hospital January 2016 to December 2018. The parameters of CEUS perfusion in the lesion area were obtained. Independent sample t test was used to analyze the differences of quantitative parameters between benign and malignant lesions. The receiver operating characteristic (ROC) curve was used to evaluate the value of conventional ultrasound, quantitative analysis of CEUS and their combination for the differential diagnosis of benign and malignant intraductal lesions of breast. Results · There were 42 benign lesions and 29 malignant lesions. Among the quantitative parameters of CEUS, time to peak (t2.072, P0.042), peak intensity (t-2.629, P0.011), rise slope rate (t3.015, P0.004) and the area under the curve (AUC) (t3.308, P0.001) were statistically significant. The sensitivity, specificity, accuracy, positive predictive value, negative predictive value and area under the ROC curve of conventional ultrasound were 31.03%, 90.48%, 66.20%, 69.20%, 65.50% and 0.608. Those of quantitative analysis of CEUS were 75.86%, 71.43%, 73.24%, 64.70%, 81.10% and 0.776. And those of their combination were 86.21%, 97.62%, 92.96%, 96.15%, 91.11% and 0.943. Conclusion · Conventional ultrasound is of limited value in the diagnosis of breast intraductal lesions, and quantitative analysis of CEUS is of great significance in differentiating benign malignant breast intraductal lesions. The combination of conventional ultrasound and quantitative analysis of CEUS can significantly improve the diagnostic value.

Key words: breast intraductal lesions, contrast-enhanced ultrasound, time-intensity curve (TIC)