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Meta-analysis of Asn680Ser polymorphism of follicle stimulating hormone receptor and susceptibility of polycystic ovary syndrome

QIU Lei1, ZENG Yu2, LIU Jing2, HEI Qi-ming2, WANG Da-hong2   

  1. 1.Department of Social Medicine, 2.Department of Health Management, Hainan Medical University, Haikou 571199, China
  • Online:2014-04-28 Published:2014-05-13


Objective To evaluate the correlation of the single-nuleotide polymorphism (Asn680Ser polymorphism) of follicle-stimulating hormone receptor (FSHR) and the susceptibility of polycystic ovarian syndrome (PCOS) by the meta-analysis. Methods Databases including the Pubmed, Ovid, EMBASE, CBM, and CNKI were searched to collect the case-control studies on the correlation of the Asn680Ser polymorphisms of FSHR gene and PCOS susceptibility. Records before January, 2013 were retrieved. Records were screened independently by two reviewers according to the inclusion and exclusion criteria. Data were extracted and the quality was evaluated. Then the data were analyzed by the meta-analysis using the Stata 11.0 software and the Begg's funnel plot was used to assess the publishing bias of articles. Results Totally 11 articles were selected, which involved 1 344 cases and 3 885 controls. The results of meta-analysis showed that there were significant differences between the two groups for the dominant, recessive, and addictive genetic models, and the pooled OR (95%CI) were 1.19(1.02~1.39), 1.21(1.00~1.45), 1.27(1.02~1.58), respectively. The differences were statistically significant (P<0.05). Conclusion The Asn680Ser polymorphisms of FSHR gene are associated with the susceptibility of PCOS. Ser allele of Asn680Ser is a risk factor of the PCOS for the dominant, recessive, and addictive genetic models.

Key words: follicle stimulating hormone receptor, polycystic ovarian syndrome, meta-analysis, single-nucleotide polymorphism