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Advances of protein kinase C beta and diabetic nephropathy

ZHAO Ming-ming, LIU Li-mei   

  1. Shanghai Diabetes Institute,Department of Endocrinology and Metabolism, the Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai 200233, China
  • Online:2014-04-28 Published:2014-05-13
  • Supported by:

    National Natural Science Foundation of China, 81270876，30771022，30971384；Outstanding Academic Leaders Foundation of Science and Technology Commission of Shanghai Municipality，10XD1403400

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Abstract:

Two isoforms of protein kinase C (PKC), i.e. PKC-βI and -βⅡ, which are encoded by the PRKCB1 gene, play important roles in the development and progression of diabetic nephropathy through the PKC signaling pathway. PKC-β inhibitor can reduce the thickness of glomerular basement membrane and microalbuminuria to protect the renal functions of diabetes patients. Polymorphisms and variants of PRKCB1 gene are relevant to increasing the risk of diabetic nephropathy and end stage renal disease by affecting its transcriptional activity, increasing insulin resistance, and promoting endothelial oxidative stress. This paper reviews the research progresses on the relationship between PKC-β and diabetic nephropathy.

Key words: protein kinase C-β, diabetic nephropathy, PRKCB1 gene