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Advances of DAF-2/IGF-1 signaling pathway relevant to aging in Caenorhabditis elegans

MAO Yu-qin, HAN San-feng, WANG Li-shun   

  1. Center for Molecular Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
  • Online:2014-06-28 Published:2014-06-30

Abstract:

Ageing is one of the key factors that cause many diseases. Up-to-date, most knowledge and information about the genetics of ageing in biology comes from the studies on Caenorhabditis elegans (C.elegans). The C.elegans plays an important role in the study of anti-ageing. The first aging regulation mechanism understood by the people is the DAF-2/IGF-1 signal pathway. This paper reviews the leading and promoting effects of C.elegans, which acts as a model organism, on the course of research of the DAF-2/IGF-1 signal pathways and provides helpful ideas and methods for anti-ageing studies.

Key words: Caenorhabditis elegans, ageing, DAF-2, IGF-1