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MAO Yu-qin, HAN San-feng, WANG Li-shun
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Abstract:
Ageing is one of the key factors that cause many diseases. Up-to-date, most knowledge and information about the genetics of ageing in biology comes from the studies on Caenorhabditis elegans (C.elegans). The C.elegans plays an important role in the study of anti-ageing. The first aging regulation mechanism understood by the people is the DAF-2/IGF-1 signal pathway. This paper reviews the leading and promoting effects of C.elegans, which acts as a model organism, on the course of research of the DAF-2/IGF-1 signal pathways and provides helpful ideas and methods for anti-ageing studies.
Key words: Caenorhabditis elegans, ageing, DAF-2, IGF-1
MAO Yu-qin, HAN San-feng, WANG Li-shun. Advances of DAF-2/IGF-1 signaling pathway relevant to aging in Caenorhabditis elegans[J]. , doi: 10.3969/j.issn.1674-8115.2014.06.033.
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URL: https://xuebao.shsmu.edu.cn/EN/10.3969/j.issn.1674-8115.2014.06.033
https://xuebao.shsmu.edu.cn/EN/Y2014/V34/I6/929