Correlation between 11β-hydroxysteroid dehydrogenase and metabolic syndrome

doi:10.3969/j.issn.1674-8115.2014.06.032

Abstract

Abstract:

Metabolic syndrome (MetS) is a pathological condition of disorders of several metabolic components and a risk factor of causing cardiovascular diseases and diabetes. Dysregulation of glucocorticoid is an important feature of MetS. 11β-hydroxysteroid dehydrogenase (11β-HSD) of the body mainly converts the active glucocorticoid to its inactive precursor and regulates the concentration of local glucocorticoid. 11β-HSD involves pathophysiologic processes of MetS such as insulin resistance, obesity, type 2 diabetes, and hypertension. The application of 11β-HSD1 inhibitors may provide new methods for treating MetS.

Key words: metabolic syndrome, 11β-hydroxysteroid dehydrogenases, cardiovascular diseases, diabete, 11β-hydroxysteroid dehydrogenases inhibitors

RUAN Li-li, ZOU Chao-chun. Correlation between 11β-hydroxysteroid dehydrogenase and metabolic syndrome[J]. , doi: 10.3969/j.issn.1674-8115.2014.06.032.

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Correlation between 11β-hydroxysteroid dehydrogenase and metabolic syndrome

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