Journal of Shanghai Jiao Tong University (Medical Science) ›› 2024, Vol. 44 ›› Issue (6): 755-761.doi: 10.3969/j.issn.1674-8115.2024.06.011
• Evidence-based medicine • Previous Articles Next Articles
YU Yang(), MENG Dan, QIU Yiwen, YUAN Jian, ZHU Yingjie(
)
Received:
2024-01-06
Accepted:
2024-02-28
Online:
2024-06-28
Published:
2024-06-11
Contact:
ZHU Yingjie
E-mail:yuyangyyy1004@163.com;lh2197@shutcm.edu.cn
Supported by:
CLC Number:
YU Yang, MENG Dan, QIU Yiwen, YUAN Jian, ZHU Yingjie. Analysis of impact of type 1 diabetes on colorectal cancer by using two-sample Mendelian randomization[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2024, 44(6): 755-761.
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Exposure | Outcome | MR method | P value | OR (95%CI) |
---|---|---|---|---|
Type 1 diabetes | Colorectal cancer | IVW | 0.003 4 | 1.000 7 (1.000 2‒1.001 1) |
MR-Egger | 0.001 3 | 1.001 1 (1.000 5‒1.001 8) | ||
Weighted median | 3.39×10-5 | 1.001 0 (1.000 5‒1.001 4) | ||
Simple mode | 0.671 9 | 1.000 3 (0.998 8‒1.001 9) | ||
Weighted mode | 0.000 1 | 1.001 0 (1.000 6‒1.001 4) |
Tab 1 Effect of type 1 diabetes on colorectal cancer using five MR methods
Exposure | Outcome | MR method | P value | OR (95%CI) |
---|---|---|---|---|
Type 1 diabetes | Colorectal cancer | IVW | 0.003 4 | 1.000 7 (1.000 2‒1.001 1) |
MR-Egger | 0.001 3 | 1.001 1 (1.000 5‒1.001 8) | ||
Weighted median | 3.39×10-5 | 1.001 0 (1.000 5‒1.001 4) | ||
Simple mode | 0.671 9 | 1.000 3 (0.998 8‒1.001 9) | ||
Weighted mode | 0.000 1 | 1.001 0 (1.000 6‒1.001 4) |
Exposure | Outcome | MR method | P value | OR (95%CI) |
---|---|---|---|---|
Colorectal cancer | Type 1 diabetes | IVW | 0.373 2 | 0.013 8 (1.12×10-6‒171.093 6) |
MR-Egger | 0.643 6 | 0.000 3 (3.23×10-18‒2.96×10-10) | ||
Weighted median | 0.273 9 | 0.000 8 (2.34×10-9‒279.941 3) | ||
Simple mode | 0.247 1 | 3.36×10-6 (1.82×10-14‒745.124 1) | ||
Weighted mode | 0.266 8 | 4.42×10-5 (4.18×10-12‒426.783 2) |
Tab 2 Effect of colorectal cancer on type 1 diabetes using five MR methods
Exposure | Outcome | MR method | P value | OR (95%CI) |
---|---|---|---|---|
Colorectal cancer | Type 1 diabetes | IVW | 0.373 2 | 0.013 8 (1.12×10-6‒171.093 6) |
MR-Egger | 0.643 6 | 0.000 3 (3.23×10-18‒2.96×10-10) | ||
Weighted median | 0.273 9 | 0.000 8 (2.34×10-9‒279.941 3) | ||
Simple mode | 0.247 1 | 3.36×10-6 (1.82×10-14‒745.124 1) | ||
Weighted mode | 0.266 8 | 4.42×10-5 (4.18×10-12‒426.783 2) |
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