Abstract:

Induced pluripotent stem cells (iPSCs) technology reprograms differentiated somatic cells and induces them to pluripotent stem cells. At present many novel technologies have improved the transfection efficiency and clinical safety of iPSCs. Neural precursor cells, glial cells, and neuron-like cells derived from iPSCs can be transplanted to treat neurological diseases and the results show good prospects. The iPSCs technology can also be used to establish models of relevant diseases in vitro and screen drugs. This paper reviews the applications of iPSCs in neurological diseases.

Key words: induced pluripotent stem cells, neurological diseases, drugs profiling