Abstract:

Objective  To investigate the changes of plasma adrenomedullin (ADM) of patients with early ectopic pregnancy and the value for early diagnose of ectopic pregnancy. Methods  A total of 50 patients with ectopic pregnancy who had menopause for 5-7 weeks were selected as subjects and 140 women with normal singleton pregnancy were selected as controls. All patients were admitted in International Peace Maternity and Child Health Hospital affiliated to Shanghai Jiao Tong University School of Medicine and Jiangwan Hospital of Shanghai Hongkou District from March to December 2014. The scatter diagram was plotted and the correlation between ADM level and weeks of menopause were observed. Critical points of ADM were analyzed by receiver operator characteristic (ROC) curves. Results  ①Being increase with menopause weeks was the overall trend of plasmatic ADM level of 140 controls and the correlation coefficient r was 0.283 (P<0.05). ②The plasmatic ADM levels of 50 patients with ectopic pregnancy were always low, which did not change a lot with the increase of menopause weeks. The correlation coefficient was 0.186 (P>0.05). ③The multiple of median of 7 menopause weeks of patients was obviously lower than that of controls (P<0.05). ④ROC curves was used to analyze critical points of ADM for the diagnosis of ectopic pregnancy (P>0. 05). Conclusion  The ADM levels of patients with early ectopic pregnancy were low and did not change significantly with the increase of menopause weeks, but using it as an index of early diagnosis of ectopic pregnancy is not statistically significant (P>0.05).

Key words: adrenomedullin, early pregnancy, ectopic pregnancy