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Comparison of pressure support ventilation and controlled mechanical ventilation in lung injury model

WU Jing-bo, ZHOU Wen-xian, WU Li-zhen, WANG Xue-ling, CAI Jie-heng   

  1. Department of Anaesthesiology, the First Affiliated Hospital of Guangdong College of Pharmacy, Guangzhou 510080, China
  • Online:2015-09-28 Published:2015-09-30
  • Supported by:

    Guangdong Province Medical Science and Technology Research Foundation, A2013330


Objective  To determine the long-term effect of pressure support ventilation (PSV) on experimental lung injury. Methods  The animal model of acute lung injury (ALI) was established by repetitive lung lavage for 20 healthy adult female rabbits. Rabbits were randomly divided into the PSV group (n=10) with the pressure level of tidal volume>4 mL/kg and respiratory rate of <40/min and controlled mechanical ventilation (CMV) group (n=10) with the pressure level of tidal volume of 4 mL/kg and respiratory rate of 20/min. The positive end-expiratory pressure of two groups was set at 10 cmH2O. Blood gas analysis and determination of ventilation-perfusion (VA/Q) distribution were performed at the onset of ALI and 2, 4, 8, and 12h after the onset of ALI. Results  The oxygenation of PSV group improved remarkably because the pulmonary shunt remarkably decreased and the area with normal VA/Q ratio increased. Compared with the PSV group, the pulmonary shunt of CMV group significantly decreased (P<0.05). Conclusion  PSV remarkably improves the gas exchange by reducing the inequality of VA/Q in the animal model of ALI. However, as far as the improvement of VA/Q distribution is concerned,  CMV is more effective than PSV.

Key words: acute lung injury, pressure support ventilation, ventilation-perfusion distribution, pulmonary shunt