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Research advances in the roles of lipoxin in acute lung injury and its mechanisms

ZHANG Rong, ZHANG Yi-wei, WANG Yan, QI Ai-hua, WANG Li, WANG Ai-zhong   

  1. Department of Anesthesiology, Shanghai Sixth People’s Hospital, Shanghai Jiao Tong University, Shanghai 200233, China
  • Online:2016-06-28 Published:2016-07-25
  • Supported by:

    National Natural Science Foundation of China, 81272147


Acute lung injury (ALI) and its severe phase, i.e. acute respiratory distress syndrome (ARDS), is a common critical disease characterized by noncardiac pulmonary edema and refractory hypoxemia with high mortality, which seriously threatens patients’ lives. As a potent endogenous counter-regulatory lipid mediator, lipoxin (LX) plays a key role in the pathogenesis of many diseases such as ALI/ARDS and becomes a research focus in recent years. This paper reviews research advances in the roles of LX in ALI/ARDS and its mechanisms.

Key words: lipoxin, acute lung injury, acute respiratory distress syndrome, inflammation, pro-resolution