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Research advances in the roles of ncRNAs in polycystic ovary syndrome

YANG Qian1, ZHOU Cheng-liang2, PAN Jie-xue1, HUANG He-feng1，2   

  1. 1.Institute of Embryo-Fetal Original Adult Disease, The International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030， China; 2.The Key Laboratory of Reproductive Genetics（Ministry of Education）， Womens Hospital School of Medicine Zhejiang University, Hangzhou 310058， China
  • Online:2016-06-28 Published:2016-07-25
  • Supported by:

    The National Key Technology R&D Program， 2012BAI32B00； National Natural Science Foundation of China， 81450038

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Abstract:

Polycystic ovary syndrome (PCOS) is a common reproductive system disease affecting approximately 5% to 10% of women of childbearing age. The pathogenesis of PCOS remains unclear despite increasing studies in recent years. ncRNAs are RNAs not translating into proteins and mainly involve in many important functions such as regulation of gene expression and epigenetics. ncRNAs become a research hotspot recently. Previous studies have found changes in expressions of various ncRNAs in serum, follicle fluid, and granulosa cells of PCOS patients. It may be a new target for the diagnose of PCOS and provide new idea for studying the pathogenesis of PCOS. This paper reviews recent research advances in the roles of ncRNA in the occurrence and development of PCOS.

Key words: polycystic ovary syndrome, ncRNA, microRNA, lncRNA