Abstract:

Acute lung injury (ALI) and its severe phase, i.e. acute respiratory distress syndrome (ARDS), is a common critical disease characterized by noncardiac pulmonary edema and refractory hypoxemia with high mortality, which seriously threatens patients’ lives. As a potent endogenous counter-regulatory lipid mediator, lipoxin (LX) plays a key role in the pathogenesis of many diseases such as ALI/ARDS and becomes a research focus in recent years. This paper reviews research advances in the roles of LX in ALI/ARDS and its mechanisms.

Key words: lipoxin, acute lung injury, acute respiratory distress syndrome, inflammation, pro-resolution