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Research progress in molecular mechanisms of ectodermal dysplasias and birth defects of offspring

GU Ben-hong1, 2, TIAN Ru-hui1, LI Zheng1   

  1. 1. Department of Andrology/Pelvic Floor Dysfunction, Department of Assisted Reproductive Technology, Institute of Urology Center for Men's Health, Urologic Medical Center, Shanghai General Hospital, Shanghai Key Lab of Reproductive Medicine, Shanghai Jiao Tong University, Shanghai 200080, China; 2. Department of Urology, Pudong New-area Traditional Chinese Medicine Hospital , Shanghai 201299, China
  • Online:2017-02-28 Published:2017-02-28
  • Supported by:

    National Key Basic Research Program of China（973 Program）, 2012CB96603; Frontier Technology Project of Shanghai, SHDC12015122

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Abstract:

The ectodermal dysplasias (ED), sharing common clinical manifestations, are a large group of heterogenous hereditary disorders, characterized by alterations of structures of ectodermal origin, such as skin, sweat glands, hair, nails and teeth. Besides these organs, central nervous system, peripheral
nervous system, eyes, ears, and nose, as well as eccrine, mammary, and pituitary glands are all derived from the ectoderm. To varying degrees, the offsprings inherited of ED have birth defects and their health will be influenced. This paper reviews recent results of molecular researches and clinical
therapy improvements about ED.

Key words: ectodermal dysplasias, birth defect, NF-κB