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Research progress of mechanisms outer membrane proteins of Helicobacter pylori and its adherence

ZHAO Qiao-yun, XIE Yong   

  1. Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, China
  • Online:2017-02-28 Published:2017-02-28
  • Supported by:

    National Natural Science Foundation of China, 81260076


Helicobacter pylori is a predominant pathogen inducing long-term chronic infection of stomach. Its outer membrane proteins (OMPs) mainly include lipoprotein, fimbriae protein and some adhesions. The adhesions are closely related to the pathogenic processes of adherence, colonization, persistent infection and severe clinical outcomes. In addition, the fact that adherence is vital for colonization and pathogenicity has made it a focus to study the vaccines against adherence. The OMPs related to adherence, their receptors, mechanisms of adherence, and the vaccines are summarized in this review.

Key words: Helicobacter pylori, outer membrane proteins, adherence, vaccine