›› 2017, Vol. 37 ›› Issue (8): 1165-.doi: 10.3969/j.issn.1674-8115.2017.08.023

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Role of myosin regulatory light chain phosphorylation in the pathogenesis of chronic heart failure#br#

HU Shan, WU Gang   

  1. Department of Cardiology, Cardiovascular Research Institute, Hubei Key Laboratory of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, China
  • Online:2017-08-28 Published:2017-09-28
  • Supported by:
    National Natural Science Foundation of China, 81270305, 81670363

Abstract:  In the embryonic period, myosin regulatory light chain (MYL2) plays a pivotal role in the development and function of the heart. A large number of studies have previously confirmed that the mutation of MYL2 gene, also known as MLC2, confers intimate associations with hypertrophic cardiomyopathy. MYL2 gene mutation impacts the structure and function of myosin, thereby leading to the occurrence and progression of hypertrophic and dilated cardiomyopathy as well as the following chronic heart failure. Importantly, MYL2 phosphorylation renders crucial effects in the processes of cardiac contraction, ventricular torsion and cardiac function.

Key words: myosin regulatory light chain, chronic heart failure, phosphorylation, myocardial contractility