›› 2018, Vol. 38 ›› Issue (5): 552-.doi: 10.3969/j.issn.1674-8115.2018.05.014

• Review • Previous Articles     Next Articles

Research progress of microglia and peripheral monocytes in mood disorders

MAO Rui-zhi1, 2, ZHANG Chen1, 2, FANG Yi-ru1, 2   

  1. 1. Division of Mood Disorder; 2. Biochemical Laboratory, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
  • Online:2018-05-28 Published:2018-05-28
  • Supported by:
    “12th Five-year Plan”of National Key Technologies R&D Program, 2012BAI01B04;“13th Five-year Plan”of National Key R&D Program, 2016YFC1307100; National Natural Science Foundation of China, 91232719, 81771465; National Key Clinical Disciplines at Shanghai Mental Health Center, OMA-MH 2011-873; Shanghai Clinical Center for Mental Disorders, 2014

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Abstract: The role of inflammation in the pathomechanism and treatment of mood disorders has drawn public attention in the field. As representatives of central and peripheral immune systems, microglia and peripheral monocytic cells become more active and release relative cytokines in mood disorders patients. These two classes of immune cells have similar genetic and functions. It is beneficial to explore how microglia and monocytes influence emotion and behavior via immune signaling pathway for understanding the disease pathogenesis and developing potential therapeutic strategies.

Key words: microglia, peripheral monocyte, mood disorders, inflammation, major depressive disorder, bipolar disorder

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