Research progress of microglia and peripheral monocytes in mood disorders

doi:10.3969/j.issn.1674-8115.2018.05.014

›› 2018, Vol. 38 ›› Issue (5): 552-.doi: 10.3969/j.issn.1674-8115.2018.05.014

• Review • Previous Articles Next Articles

Research progress of microglia and peripheral monocytes in mood disorders

MAO Rui-zhi1, 2, ZHANG Chen1, 2, FANG Yi-ru1, 2

1. Division of Mood Disorder; 2. Biochemical Laboratory, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China

Online:2018-05-28 Published:2018-05-28
Supported by:
“12th Five-year Plan”of National Key Technologies R&D Program, 2012BAI01B04;“13th Five-year Plan”of National Key R&D Program, 2016YFC1307100; National Natural Science Foundation of China, 91232719, 81771465; National Key Clinical Disciplines at Shanghai Mental Health Center, OMA-MH 2011-873; Shanghai Clinical Center for Mental Disorders, 2014

Abstract

Abstract: The role of inflammation in the pathomechanism and treatment of mood disorders has drawn public attention in the field. As representatives of central and peripheral immune systems, microglia and peripheral monocytic cells become more active and release relative cytokines in mood disorders patients. These two classes of immune cells have similar genetic and functions. It is beneficial to explore how microglia and monocytes influence emotion and behavior via immune signaling pathway for understanding the disease pathogenesis and developing potential therapeutic strategies.

Key words: microglia, peripheral monocyte, mood disorders, inflammation, major depressive disorder, bipolar disorder

CLC Number:

R749.4

MAO Rui-zhi1, 2, ZHANG Chen1, 2, FANG Yi-ru1, 2. Research progress of microglia and peripheral monocytes in mood disorders[J]. , 2018, 38(5): 552-.

[1]	Mei Zixian, Meng Xuchen, Su Wenjing, Zhong Weijie, Tang Dingzhong, Li Yi. Clinical-inflammatory combined model for predicting poor prognosis in male patients with anterior circulation acute ischemic stroke with large vessel occlusion after mechanical thrombectomy [J]. Journal of Shanghai Jiao Tong University (Medical Science), 2026, 46(3): 332-339.
[2]	Wu Kexin, Lu Jia, Wu Xingyu, Yu Zhihua. Role of microglial TRPV1 in apolipoprotein E4-associated Parkinson's disease [J]. Journal of Shanghai Jiao Tong University (Medical Science), 2026, 46(2): 163-171.
[3]	Liu Wenxia, Zhang Chen. Research advances in the impact of childhood trauma on anhedonia in schizophrenia via immune-inflammatory pathways [J]. Journal of Shanghai Jiao Tong University (Medical Science), 2026, 46(2): 235-240.
[4]	Xie Yixia, Wang Fan, Liu Xirui, Chen Ningning, Zhang Wenxuan, Wu Jialin, Ma Ting, Hong Wu. Overview of mechanisms of adult major depressive disorder comorbid attention deficit hyperactivity disorder and the prospects of transcranial direct current stimulation [J]. Journal of Shanghai Jiao Tong University (Medical Science), 2026, 46(1): 107-114.
[5]	Han Zhen, Wang Hao, Su Xiuxiu, Fang Ji. Hypericin alleviates podocyte injury in diabetic nephropathy by inhibiting the NF-κB signaling pathway [J]. Journal of Shanghai Jiao Tong University (Medical Science), 2026, 46(1): 43-53.
[6]	KERANMU Saitierguli, QIAN Lei, DING Siyi, MAHELIMUHAN Hanati, YANG Xueer, JIA Hao. Research progress of arginine metabolism in the regulation of mesenchymal stem cell function [J]. Journal of Shanghai Jiao Tong University (Medical Science), 2025, 45(7): 910-915.
[7]	ZHAO Xinyu, ZHANG Wenchao, CHEN Xuzhuo, SONG Jiaqi, HUANG Hui, ZHANG Shanyong. Study on the effects of spermidine on LPS-induced inflammatory osteolysis in mouse calvaria [J]. Journal of Shanghai Jiao Tong University (Medical Science), 2025, 45(6): 673-683.
[8]	YANG Le, ZHOU Yi, WANG Keyun, LAI Yali. Research on the improvement of cognitive impairment, endoplasmic reticulum stress and neuroinflammation in Alzheimer's disease by emodin [J]. Journal of Shanghai Jiao Tong University (Medical Science), 2025, 45(6): 727-734.
[9]	YU Kai, SHUAI Zhewei, HUANG Hongjun, LUO Yan. Research progress on the role and mechanisms of microglia in inflammatory diseases of central nervous system [J]. Journal of Shanghai Jiao Tong University (Medical Science), 2025, 45(5): 630-638.
[10]	WANG Sirui, KONG Gai, LI Hui, QIAN Zhenying, CUI Huiru, TANG Yingying. Impact of transcranial magnetic stimulation therapy on the volumes of amygdala and hippocampal subfields in patients with major depressive disorder [J]. Journal of Shanghai Jiao Tong University (Medical Science), 2025, 45(4): 434-442.
[11]	WAN Hongjin, HU Yibin, WANG Xin, ZHANG Kai, QIN An, MA Peixiang, MA Hui, ZHAO Jie. Neferine alleviates intervertebral disc degeneration through KEAP1/NRF2/GPX4 and NF-κB signaling pathways [J]. Journal of Shanghai Jiao Tong University (Medical Science), 2025, 45(3): 261-270.
[12]	WANG Xiaohong, FANG Yiru. Research progress on the neuroinflammation mechanisms in bipolar disorder [J]. Journal of Shanghai Jiao Tong University (Medical Science), 2025, 45(1): 107-112.
[13]	CAI Qiangwei, SUN Feng, WU Wenyu, SHAO Fuming, GAO Zhengliang, JIN Shengkai. Transcriptional regulatory network analysis of microglia in multiple sclerosis [J]. Journal of Shanghai Jiao Tong University (Medical Science), 2025, 45(1): 29-41.
[14]	CHEN Shentse, CHEN Yiming, WANG Fan, ZHANG Mengke, YANG Weichieh, LÜ Dongbin, HONG Wu. Advances in dietary interventions for the treatment of depression-related symptoms [J]. Journal of Shanghai Jiao Tong University (Medical Science), 2024, 44(8): 1050-1055.
[15]	CHEN Minghao, LIU Peiyu, WANG Xuan, WU Yixiang, JIANG Yujin, ZHANG Chaoyang, ZHANG Jingfa. Advances in drug therapy of diabetic retinopathy [J]. Journal of Shanghai Jiao Tong University (Medical Science), 2024, 44(7): 822-829.

Research progress of microglia and peripheral monocytes in mood disorders

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

TrendMD

References

Related Articles 15

Recommended Articles

Metrics

Comments