Abstract: Objective · To observe the clinical effect of Wenjing-Quyu-Juanbi Prescription combined with methylcobalamin on chemotherapy-induced peripheral neuropathy (CIPN). Methods · A total of 133 CIPN patients were dividedrandom number method into two groups, i.e. treatment group (n67) and control group (n66). Control group received oral methylcobalamin therapy, and treatment group received water decoction of WenjingQuyu-Juanbi Prescription on the basis of oral methylcobalamin therapy every day. After 4 weeks of treatment, the patients symptom scores in traditional Chinese medicine and peripheral nerve injury grades in two groups were observed and total effective rates were calculated. The peripheral nerve conductive velocities between the two groups were compared. Results · The study was completed in 123 patients, 63 in the treatment group and 60 in the control group. After treatment, symptom scores of numbness of the extremities, pain, inconvenient flexion, mental fatigue, pale appearance and cold limbs were significantly lower than those before treatment (all P<0.05). And the symptom scores of treatment group after treatment were significantly lower than those of control group (all P<0.05). The total effective rate of treatment for peripheral nerve injury in treatment group was also higher than that in control group (P<0.05). Sensory nerve conduction velocity and motor nerve conduction velocity of median nerves and common peroneal nerves after treatment were all significantly faster than those before treatment (all P<0.05). And between the two groups they were faster in treatment group after treatment (P<0.05). Conclusion · The therapeutic effect of Wenjing-Quyu-Juanbi Prescription combined with methylcobalamin on CIPN is better than that of methylcobalamin only.

Key words: Wenjing-Quyu-Juanbi Prescription, methylcobalamin, malignant tumor, chemotherapy-induced peripheral neuropathy随着恶性肿瘤发病率逐年上升, 临床抗肿瘤化学治成为主要不良反应之一, 临床表现为肢体对称性的感觉异疗（简称化疗）药物的应用也愈发广泛, 在提高抗肿常、麻木如蚁爬、疼痛、发凉或伴有腱反射消失、运动失瘤疗效的同时也带来了许多不良反应。因使用奥沙利调等, 严重者甚至直接影响到化疗的顺利完成 [1]。甲钴胺铂、紫杉醇、长春新碱等化疗药物导致的周围神经病变是西医防治 CIPN的常用药物之一, 作为维生素 B12的衍（chemotherapy-induced peripheral neuropathy, CIPN）已经生物, 外源性用药可进入神经细胞, 提高甲硫氨酸合成