Abstract: Objective · To investigate the clinicopathological risk factors of spread through air space (STAS) in stage Ⅰ A lung adenocarcinoma. Methods · The clinical data of patients with stage Ⅰ A lung adenocarcinoma who underwent lung surgery in Shanghai Chest Hospital, Shanghai Jiao Tong University from Jan. 2018 to Oct. 2019 were retrospectively collected. According to whether STAS happened, the patients were divided into STAS group and non-STAS group. Univariate analysis and binary Logistic regression analysis were used to analyze the risk factors of STAS in stage Ⅰ A lung adenocarcinoma between the two groups. Results · A total of 1 365 patients with stage Ⅰ A lung adenocarcinoma were included, including 1 312 patients without STAS and 53 patients with STAS. Univariate analysis showed that there were significant differences in gender and major subtypes of lung adenocarcinoma between the two groups (both P=0.000), but there was no significant difference in T stage between the two groups. Binary Logistic regression analysis showed that male and non-lepidic subtypes were independent risk factors. Conclusion · For the treatment of stage Ⅰ A lung adenocarcinoma, especially those with micropapillary subtype, the clinicians should pay attention to the possibility of STAS.

Key words: lung adenocarcinoma, micropapillary, spread through air space (STAS)