JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE) ›› 2020, Vol. 40 ›› Issue (08): 1126-1130.doi: 10.3969/j.issn.1674-8115.2020.08.021

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Role of bile acid on maintaining metabolic homeostasis

LI Sen1, JIA Zi-heng1, WEI Xue-rui1, MA Sai1, LU Tian-cheng1, LI Ting-ting2, GU Yan-yun2   

  1. 1. Ruijin Clinical Medical College, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; 2. Department of Endocrinology and Metabolism, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Clinical Medical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai 200025, China
  • Online:2020-08-28 Published:2020-08-28
  • Supported by:
    The 13th Undergraduate Training Program for Innovation of Shanghai Jiao Tong University School of Medicine (1319193); National Natural Science Foundation of China (81870555); Innovative Research Team of High-Level Local Universities in Shanghai.

Abstract: Bile acids are the main products of the cholesterol degradation in the liver. They promote the absorption and transportation of the intestinal lipids. Diverse bile acid receptors are widely distributed in human tissues and organs, including farnesoid X receptor (FXR) and Takeda G protein receptor (TGR5). The expression pattern of different bile acid receptors and their different affinities to various bile acids as their ligands determines their pleiotropic downstream effects, including regulating bile acid synthesis and transportation, immune and metabolism homeostasis. In addition, the bile acid pool includes components derived from both host and gut microbiota, which collaboratively contribute to the bile acid signaling activation in different compartments. Therefore, bile acid pool represents an information hub allowing the crosstalk between the host and gut microbiome and hereby modulating host metabolic homeostasis and gut microbiome symbiosis. This article reviews the recent advances in the field of bile acid regulation and the related mechanisms of bile acid signaling pathway to maintain metabolic homeostasis.

Key words: bile acid, bile acid receptor, glucose metabolism, inflammation

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