JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE) ›› 2020, Vol. 40 ›› Issue (08): 1152-1156.doi: 10.3969/j.issn.1674-8115.2020.08.026

• Review • Previous Articles    

Research progress in diagnosis and treatment of eosinophilic gastroenteritis

BAI Ya-ya, YAO Wei-yan   

  1. Department of Gastroenterology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
  • Online:2020-08-28 Published:2020-08-28

Abstract: Eosinophilic gastroenteritis (EGE) is a rare chronic disease of digestive system, characterized by the eosinophil in?ltration of the gastrointestinal tract and the thickening of the gastrointestinal wall. At present, the etiology and pathogenesis of EGE are still unclear. Accompanied with eosinophilia and elevation of serum immunoglobulin E, the clinical manifestations of EGE are dependent on the location of lesions and the extent or depth of eosinophil in?ltration in the gastrointestinal tract. The thickening or edema of the gastrointestinal wall, nodular-like changes, intestinal stenosis and ascites can be regarded as common radiological findings of EGE, while erythema, hyperemia or edema, erosion and ulcer of mucosal are the endoscopic features of EGE. Tissue biopsy is helpful for the diagnosis of EGE. However, with unspecific clinical manifestations, laboratory tests, radiological and endoscopic findings and unidentified cut-off count of pathological diagnostic criteria, EGE is very difficult to be diagnosed. Therefore, this paper mainly reviews the research progress in the diagnosis and treatment of EGE, attempting to improve the clinicians' understanding of EGE.

Key words: eosinophilic gastroenteritis (EGE), etiology, pathogenesis, clinical manifestation, diagnosis, therapy

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