JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE) ›› 2021, Vol. 41 ›› Issue (4): 535-539.doi: 10.3969/j.issn.1674-8115.2021.04.020

• Review • Previous Articles     Next Articles

Progress of catabolite control protein A in the regulation of metabolism and virulence of Gram-positive bacteria

Zi-yu YANG(), Juan-xiu QIN, Min LI, Qian LIU()   

  1. Department of Laboratory Medicine, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
  • Received:2020-03-13 Online:2021-04-28 Published:2021-05-14
  • Contact: Qian LIU;
  • Supported by:
    National Natural Science Foundation of China(81772139);Innovative Research Team of High-Level Local Universities in Shanghai(SSMU-ZLCX20180701);Cultivation Fund from Renji Hospital, Shanghai Jiao Tong University School of Medicine(PYIII-17-001)


Catabolite control protein A (CcpA) is an important pleiotropic regulator in Gram-positive bacteria. With the assistance of the phosphoenolpyruvate-dependent carbohydrate phosphotransferase system, CcpA undergoes a conformational change and interacts with catabolite responsive element, a specific DNA sequence on the target gene, activating or repressing expression of the target gene, thereby controlling the physiological processes and virulence of bacteria. CcpA mediates the carbon catabolite repression effect of microorganisms to control the uptake and utilization of environmental nutrients, ensuring the efficient use of energy by bacteria. CcpA regulates bacterial metabolism and virulence gene expression directly or indirectly, coupling the metabolism and virulence of bacteria. This review describes the mechanism of CcpA function, and summarizes the research progress of CcpA in regulating multiple metabolic pathways and pathogenicity of bacteria.

Key words: catabolite control protein A (CcpA), carbon catabolite repression (CCR), metabolism, virulence

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