Research progress in the relationship between endosomal sorting complexes required for transport and autophagy

doi:10.3969/j.issn.1674-8115.2021.09.019

Abstract

Abstract:

Autophagy is an intracellular degradation pathway, which can transport a large number of cytoplasmic, damaged organelles and other substrates to lysosomes for degradation to maintain intracellular homeostasis. In the process of autophagy, the integrity of autophagy flow should be ensured. Many factors affect the smooth autophagy flow, including the relationship between endosomal sorting complexes required for transport (ESCRT) and autophagy. ESCRT is mainly responsible for membrane shearing, mediating cell membrane remodeling and division, and plays an important role in the process of endocytosis and cytokinesis. In recent years, many studies have shown that ESCRT mutants generally present an accumulation of autophagosomes, suggesting that autophagy flow is affected. In-depth studies indicate that ESCRT is involved in the regulation of several processes of different types of autophagy, and its subunits also interact with autophagy-related proteins. This article reviews the related research in recent years.

Key words: autophagy, endosomal sorting complexes required for transport (ESCRT), autophagosome, endosome

CLC Number:

R33-3

Yi LI, Da-wei SUN, De-rong CUI. Research progress in the relationship between endosomal sorting complexes required for transport and autophagy[J]. JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE), 2021, 41(9): 1256-1260.

Figures/Tables 2

TrendMD

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ESCRT machinery	Yeast	Human
ESCRT
ESCRT-0	Vps27	HRS
	Hse1	STAM-1
ESCRT-Ⅰ	Vps23	TSG101
	Vps28	VPS28
	Vps37	VPS37A， B， C， D
	MVB12	MVB12A， B
ESCRT-Ⅱ	Vps22	EAP30
	Vps25	VPS25
	Vps36	VPS36
ESCRT-Ⅲ	Vps2	CHMP2A， B
	Vps20	CHMP6
	Vps24	CHMP3
	Vps32/Snf7	CHMP4A， B， C
	Did2/Vps46	CHMP1A， B
	Vps60/Chm5	CHMP5
	Ist1	IST1
	Chm7	CHMP7
Accessory factor	Vps4	VPS4A， B/SKD1， 2
	Vta1	LIP5
Other
ESCRT associated factor	‒	TOM1
	Bro1	PDCD6IP/ALIX

ESCRT machinery	Yeast	Human
ESCRT
ESCRT-0	Vps27	HRS
	Hse1	STAM-1
ESCRT-Ⅰ	Vps23	TSG101
	Vps28	VPS28
	Vps37	VPS37A， B， C， D
	MVB12	MVB12A， B
ESCRT-Ⅱ	Vps22	EAP30
	Vps25	VPS25
	Vps36	VPS36
ESCRT-Ⅲ	Vps2	CHMP2A， B
	Vps20	CHMP6
	Vps24	CHMP3
	Vps32/Snf7	CHMP4A， B， C
	Did2/Vps46	CHMP1A， B
	Vps60/Chm5	CHMP5
	Ist1	IST1
	Chm7	CHMP7
Accessory factor	Vps4	VPS4A， B/SKD1， 2
	Vta1	LIP5
Other
ESCRT associated factor	‒	TOM1
	Bro1	PDCD6IP/ALIX

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