Journal of Shanghai Jiao Tong University (Medical Science) ›› 2022, Vol. 42 ›› Issue (6): 813-818.doi: 10.3969/j.issn.1674-8115.2022.06.017

• Review • Previous Articles    

Research progress of invasive functional assessment of coronary artery disease

JIANG Yue(), HE Ben()   

  1. Department of Cardiology, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
  • Received:2022-05-13 Accepted:2022-05-30 Online:2022-06-28 Published:2022-08-19
  • Contact: HE Ben;
  • Supported by:
    National Natural Science Foundation of China(81830010);Clinical Research Plan of Shanghai Shenkang Hospital Development Center(SHDC2020CR1039B)


Fractional flow reserve (FFR) is an invasive functional examination. Its diagnostic performance has been confirmed by a large number of studies. Because of its superiority to the traditional method of pure selective coronary angiography (CAG), it has now become the “gold standard” for diagnosing the severity of coronary artery disease. However, the need to use vasodilators for vascular pretreatment, poor coronary pressure guide wire passing performance, long inspection operation time and other factors make FFR limited in clinical application and could not be widely used. Therefore, derived indicators of FFR such as instantaneous wave-free ratio (iFR) and quantitative flow ratio (QFR) have been generated. Studies have confirmed that these indicators are in good agreement with FFR. In addition, these derived indicators simplify the operation process in the measurement, avoid the use of vasodilators, and can obtain functional data close to FFR at the same time, which provide reliable support for the operator and reduce the adverse effects of patients.Therefore, they are expected to be widely used in clinical practice as an alternative to FFR. In recent years, the publication of a number of important studies has provided new evidence-based data. These studies include the update of examination methodologies, the comparison of diagnostic performance, the expansion of examination scope, and the publication of long-term follow-up data, etc. This paper reviewed the related studies in recent years.

Key words: coronary artery disease, coronary functional assessment, fractional flow reverse (FFR), instantaneous wave-free ratio (iFR), quantitative flow ratio (QFR)

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