Abstract:

Objective To explore the application of hydrogen proton magnetic resonance spectroscopy（¹H-MRS）in the diagnosis of peripheral tumor cell infiltration of gliomas. Methods Forty patients with glioma were examined by ¹H-MRS preoperation, and were divided into low grade glioma group (n=20) and high grade glioma group (n=20) according to postoperative pathological diagnosis. Tumor resection with peripheral tissues marked previously was carried out under the guidance of neuronavigator system. All the pathological sections were divided into positive group and negative group according to the presence or absence of tumor cells, and the differences in pathological findings of peripheral regions (region 1, 2 and 3) and ¹H-MRS values were analyzed in these two groups. Results No infiltration was found in the peripheral regions of low grade glioma group except for one case in peripheral region 1, while infiltration was found in all peripheral regions of high grade glioma group. There was no significant difference in ¹H-MRS values between positive group (n=24) and negative group (n=36) in patients with high grade glioma (P>0.05）. Conclusion ¹H-MRS enjoys some advantages over routine radiological examinations in the diagnosis of peripheral tumor cell infiltration of gliomas. Total removal can be expected when combined with neuronavigator system, while there is room for improvement for relevant techniques.

Key words: hydrogen proton magnetic resonance spectroscopy, neuronavigator, glioma