Abstract:

Objective To evaluate the solute clearance characteristics of REXEED^TM series dialyzers during high-flux dialysis, and explore the care characteristics. Methods A randomized crossover study of 3×3 Latin square was designed based on different dialyzers. Eighteen patients with regular hemodialysis underwent dialysis with REXEED^TM-15AC dialyzer, REXEED^TM-15UC dialyzer and controlled APS-15U dialyzer, respectively. Blood samples were obtained from the blood flow entrance and exit of dialyzers, levels of urea nitrogen, creatinine, phosphate and β2microglobulin were detected, and solute clearance rates were calculated. Before and after the third dialysis with each dialyzer, blood samples were obtained to measure the levels of urea nitrogen and creatinine, and the rates of decrease were calculated. The vital signs of each patient were intensively observed, and the venous pressure and transmembrane pressure were monitored from the dialyzers. Results The urea nitrogen clearance rates of REXEED^TM-15AC dialyzer and REXEED^TM-15UC dialyzer were significantly higher than that of APS-15U dialyzer（P<0.05）. The creatinine clearance rate of REXEED^TM-15AC dialyzer was significantly higher than that of APS-15U dialyzer（P<0.05）. There was no significant difference in the rate of decrease in blood urea nitrogen among different dialyzers of the same patient（>65% for all patients）. The vital signs were stable with no adverse events during dialysis, and there was no abnormal findings in laboratory security parameters. Conclusion REXEED^TMseries dialyzers are effective and safe for clinical application. Great importance should be attached to the complaints from patients during dialysis. For those with less ultrafiltration, fluid as well as ultrafiltration should be supplemented to increase the transmembrane pressure.

Key words: high-flux hemodialysis, dialyzer, clearance, care