Abstract:

With the development of organ transplantation for nearly half a century, currently the hot issues in clinical renal transplantation have already shifted to the application of low toxicity immunosuppressive drugs and their projects, as well as the research of technique which induces low or no immunity response to the specific donor. At present the main effective strategies of inducing immune tolerance are donor specific blood transfusion and donor specific bone marrow transplantation.This article summarizes the background, mechanism and clinical application of these two strategies.

Key words: renal transplantation, donor specific blood transfusion, donor specific bone marrow transplantation, immune tolerance, chimerism