›› 2009, Vol. 29 ›› Issue (9): 1070-.

• Original article (Clinical research) • Previous Articles     Next Articles

Impact of gastroesophageal reflux disease to chronic obstructive pulmonary disease exacerbation

HU Jia-an1, CAO Zhen-ying1, XU Zhi-hong1, HUANG Shao-guang2, ZHANG Bo-ying3   

  1. 1. Department of Geriatrics, 2. Department of Respiratory Medicine, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200025, China;3. Department of Respiratory Medicine, Luwan Branch of Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200020, China
  • Online:2009-09-25 Published:2009-09-29
  • Supported by:

    Major Foundamental Research Program of Shanghai Committee of Science and Technology, 044119660


Objective To explore relationship between gastroesophageal reflux disease (GERD) and chronic obstructive pulmonary disease (COPD) and to evaluate impact of GERD on COPD exacerbation. Methods A total of 80 COPD patients (COPD group) in the Outpatient Department and 61 non-COPD male smokers (control group) were recruited in this study. All people completed diagnostic questionnaires for GERD and chronic mucus hypersecretion (CMH) and lung function test. The rates of hospital related acute exacerbations of COPD (rehospitalization and visits in Department of Emergency) in the following one-year-long follow-up were obtained. Results GERD incidences were 18.5% and 14.8% in COPD and control groups, respectively. GERD incidence in COPD patients with severe dyspnea was higher than that in patients with slight dyspnea (28.9% vs 17.1%, P>0.05). GERD was observed in 23.8% of patients with CMH, while 8.2% in patients without CMH (P<0.05). COPD patients with GERD and without GERD had similar rates of exacerbation during the one-year follow-up period. The incidences of hospital-related acute exacerbation and re-hospitalization were similar in the two groups. Conclusion GERD is not associated with COPD, exacerbation, and hospital-related exacerbations of COPD. CMH is significantly correlated with GERD, which reveals the potential role of CMH and the consideration of GERD in treating COPD patients with CMH.

Key words: gastroesophageal reflux disease, chronic obstructive pulmonary diseases, chronic mucus hypersecretion, incidence rate

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