›› 2009, Vol. 29 ›› Issue (9): 1074-.

• Original article (Clinical research) • Previous Articles     Next Articles

Effects of Stilnox on QUISI parameters in patients with insomnia

YAO Pei-fen1, CHEN Xing-shi1, ZHU Yi-sheng2, XIAO Ze-ping1, GUO Xiao-li2, WANG Ji-jun1, ZHANG Ming-dao1, LOU Fei-ying1, TANG Yun-xiang1, CHEN Chong1   

  1. 1. Shanghai Mental Health Center, School of Medicine, Shanghai Jiaotong University, Shanghai 200030, China；2. College of Life Science and Biotechnology, Shanghai Jiaotong University, Shanghai 200240, China
  • Online:2009-09-25 Published:2009-09-29
  • Supported by:

    Shanghai Municipal Health Bureau Foundation,2008L036A；Medicine and Industry Project from Shanghai Jiaotong University, YG2007MS32；National High Technology Research and Development Program of China, “863” Program, 2007AA02Z420, 2008AA02Z412；Joint Key Project of New Frontier Technology in Shanghai Municipal Hospitals, SHDC12006105

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Abstract:

Objective To investigate the effects of Stilnox on brain electrical activity in patients with insomnia using QUISI sleep instrument. Methods QUISI sleep instrument was employed  for 32 patients with insomnia for 3 consecutive nights, among whom 10 mg Stilnox was administrated before sleep on the third night, and the changes of AUISI parameters were observed after Stilnox administration. Another 28 normal controls were selected, and received one night of acclimatization and the other night of baseline QUISI monitoring. Results There were significant differences in QUISI parameters between patients with insomnia and normal controls before Stilnox administration (P<0.05 or P<0.01). Compared with those before Stilnox administration, patients with insomnia had improved sleep efficiency [(87.7±7.3%)% vs (91.4±3.8)%], reduced awake time [(40.5±15.5) min vs (22.1±6.1) min], reduced S1 [(29.9±18.3)% vs （16.1±6.5）%], increased S2 [(43.9±17.3)% vs (59.1±4.7)%] and shortened sleep latency [(35.7±17.0)min vs （21.1±11.0）min] after Stilnox administration(P<0.05 or P<0.01). Conclusion Stilnox not only can improve the subjective evaluation on sleep, but also have effects on brain electrical activity in night in patients with insomnia.

Key words: insomnia, Stilnox, QUISI, sleep disorder

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