Abstract:

Objective To investigate the relationship between serum thromboxane A2 (TXA2) and cerebral infarction. Methods Serum TXA2 contents of 72 patients with cerebral infarction and 39 normal controls were measured. The severity of symptoms and signs in 72 patients were evaluated by NIH Stroke Scale (NHISS). Results Serum TXA2 contents were significantly higher in cerebral infarction than those in controls (P=0.00). Serum TXA2 was an independent risk factor for cerebral infarction (P=0.000). Linear regression analysis showed that there was a positive correlation between serum TXA2 and NHISS in cerebral infarction (r=0.753, P=0.000). Multiple linear regression analysis indicated that serum glucose had significant effect on serum TXA2 (P=0.002). Conclusion Serum TXA2 is an independent risk factor for cerebral infarction, and there is a positive correlation between serum TXA2 and severity of cerebral infarction. Increased serum TXA2 in cerebral infarction may be associated with increased serum glucose.

Key words: thromboxane A2, cerebral infarction, serum glucose