›› 2009, Vol. 29 ›› Issue (9): 1085-.

• Original article (Clinical research) • Previous Articles     Next Articles

Comparisons of imageology in postoperative cervical lymph node metastasis of thyroid carcinoma

WANG Qiang1, YU Yong-li1, GAO Xiu-li1, ZHU Zhao-ling2   

  1. 1. Department of Nuclear Medicine, 2. Department of Ultrasound, The Sixth People's Hospital, Shanghai Jiaotong University, Shanghai 200233, China
  • Online:2009-09-25 Published:2009-09-29


Objective To explore the clinical manifestations of ultrasonography(US), 99mTc-methoxyisobutylisonitrile (99mTc-MIBI), and 131I whole body scan (131I-WBS) of patients with differentiated thyroid carcinoma(DTC)and cervical lymph node metastasis. Methods A total of 117 cases received examinations of US and 99mTc-MIBI before uses of 131I and received 131I-WBS after 6 d of 131I treatment. Combined with serum thyroglobulin(Tg), 131I-SPECT/CT, lymph node biopsy and clinical follow-up of patients, cervical lymph node metastases were identified. Results In 117 patients, the sensitivity of US, 99mTc-MIBI and 131I-WBS were 76.5%, 67.1% and 83.5%(P<0.05); the specificity of US, 99mTc-MIBI, and 131I-WBS were 75.0%, 78.1% and 84.4%; and the accuracy of US, 99mTc-MIBI and 131I-WBS were 76.1%, 70.1% and 83.8% (P<0.05), respectively. The total sensitivity, total specificity, and total accuracy of combination of the three examinations were 98.8%, 75.0% and 92.3%, respectively. Detection rates by US, 99mTc-MIBI, and 131I-WBS of 134 cervical lymph node metastasis were 75.4%, 66.4% and 80.6% (P<0.05). Combined US with 99mTc-MIBI, detection rate for 26 false-negative 131I-WBS imaging was 96.2%. Conclusion The combination of US, 99mTc-MIBI, and 131I-WBS could improve the sensitivity, specificity, and accuracy of post-operative cervical lymph node metastases of DTC. The combined results of US and 99mTc-MIBI could detect false-negative 131I-WBS imaging.

Key words: thyroid neoplasms, lymph node, 131I, ultrasonography, radionuclide imaging

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