Abstract:

Objective To study the levels of soluble endoglin (sEng) in peripheral blood and intervillous space blood of patients with preeclampsia, and analyse the correlation between levels of sEng and clinical performance. Methods Levels of sEng in peripheral blood and intervillous space blood of 22 patients with preeclampsia (preeclampsia group, 12 cases of severe preeclampsia and 10 cases of mild preeclampsia) were detected by ELISA, and the correlation between levels of sEng and blood pressure, 24 h urine protein and fetal birth weight was analysed. Twenty-two normal pregnant women were served as control group. Results The sEng levels in peripheral blood and intervillous space blood of preeclampsia group were significantly higher than those of control group [(31.89±8.80) ng/mL vs (5.24±1.60) ng/mL, P<0.01; (37.74±7.12) ng/mL vs (6.63±1.76) ng/mL, P<0.01]. In preeclampsia group, the sEng levels in peripheral blood and intervillous space blood of severe preeclampsia were significantly higher than those of mild preeclampsia (P<0.01). In preeclampsia group, the sEng level in peripheral blood was significantly correlated with that in intervillous space blood of preeclampsia group (r=0.876, P<0.01), neither was significantly correlated with blood pressure (P>0.05), both were significantly correlated with 24 h urine protein (r=0.729, P<0.01; r=0.743, P<0.01), and both were significantly correlated with fetal birth weight (r=-0.736, P<0.01; r=-0.707, P<0.01). Conclusion Levels of sEng in peripheral blood and intervillous space blood of patients with preeclampsia are significantly higher than those of normal pregnant women, and the levels of sEng are significantly correlated with the clinical performance of preeclampsia.

Key words: preeclampsia, soluble endoglin, clinical performance, correlation