Abstract:

Objective To investigate the effects of body mass index (BMI) on procedures and outcomes of in vitro fertilization and embryo transfer (IVF-ET) or intracytoplasmic sperm injection (ICSI). Methods Three hundred and twenty-three patients undergoing first long protocol for IVF-ET or ICSI were divided into group A (BMI＜18.5 kg/m2, n=43), group B (18.5 kg/m2≤BMI≤24.9 kg/m2, n=253) and group C (BMI＞24.9 kg/m2, n=27). The parameters of procedures and outcomes were compared among groups. Results Compared with group A and group B, the duration of ovarian stimulation and dose of rFSH of group C were significantly increased (P＜0.05）, while the peak oestradiol and number of big follicles on day of HCG injection and number of follicles collected were significantly decreased （P＜0.05）. There was no significant difference in the rates of fertilization, overall cancellation and clinical pregnancy among three groups（P＞0.05）. Conclusion Higher BMI may result in increased duration of ovarian stimulation and dose of rFSH, decreased peak oestradiol and number of big follicles on day of HCG injection and decreased number of follicles collected, while has no significant effect on pregnancy outcome.

Key words: body mass index, ovarian stimulation, in vitro fertilization-embryo transfer, intracytoplasmic sperm injection, pregnancy rate