Abstract:

Objective To analyse the clinical characteristics and risk factors of intracranial progressive hemorrhage after traumatic brain injury. Methods One hundred and three patients who suffered from traumatic brain injury without surgery were divided into progressive hemorrhage group (n=46) and non-progressive hemorrhage group (n=57) according to progression of intracranial hemorrhage. Age, Glasgow coma score (GCS), hours of first CT scan after injury (HCT1), hours of second CT scan after injury (HCT2), parameters of blood coagulation function at admission, hematoma volumes on first and second CT scans were compared between groups. Logistic regression analysis was conducted to analyse the risk factors of intracranial progressive hemorrhage. Results There were significant differences in age, GCS, HCT1, prothrombin time (PT), international normalized ratio (INR), fibrin degradation product (FDP), D-dimmer (D-D), platelet (PLT) count and hematoma volume on second CT scan between two groups (P<0.05). Logistic regression analysis revealed that age, FDP, INR and D-D were risk factors for intracranial progressive hemorrhage (OR>1, P<0.05), and those with lower GCS, HCT1 and PLT count were more prone to intracranial progressive hemorrhage (OR<1, P<0.05). Conclusion For patients with traumatic brain injury, age, FDP, INR and D-D are risk factors for intracranial progressive hemorrhage, and those with lower GCS, HCT1 and PLT count should be managed with intensive care.

Key words: traumatic brain injury, progressive hemorrhage, risk factors